Evidence map›Paper›PMID 36329522›Full record

ArticleCardiovascular diabetology2022

Polygenic scores for low lung function and the future risk of adverse health outcomes.

Suneela Zaigham, Isabel Gonçalves, Regeneron Genetics Center, Gunnar Engström, Jiangming Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Suneela ZaighamDepartment of Clinical Sciences Malmö, Lund University, Malmo, Sweden. suneela.zaigham@med.lu.se.
Isabel GonçalvesDepartment of Clinical Sciences Malmö, Lund University, Malmo, Sweden.
Regeneron Genetics CenterRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Gunnar EngströmDepartment of Clinical Sciences Malmö, Lund University, Malmo, Sweden.
Jiangming SunDepartment of Clinical Sciences Malmö, Lund University, Malmo, Sweden.
Lund University · SERegeneron (United States) · USUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsReduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.

methodsWe studied 27,438 middle-aged adults from the Malmö Diet and Cancer study (MDCS), followed up to 28.8 years. Trait-specific Polygenic scores (PGS) for forced expiratory volume in 1 s (FEV

resultsFEV

conclusionGenetic susceptibility for reduced lung function is associated with higher sBP, increased risk of diabetes and to a lesser extent, future coronary events, suggesting etiological roles of lung function on these outcomes. Using PGS, high-risk groups could be early detected to implement early lifestyle changes to mitigate the risk.

Indexed as

Diabetes MellitusGenetic Predisposition to DiseaseAdultHumansLungMiddle AgedOutcome Assessment, Health CareRisk FactorsDiabetesGenetic risk scoreLung functionRisk prediction

Identifiers

PMID36329522
PMCPMC9635172
OpenAlexW4308425379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.