Evidence map›Paper›PMID 36329514›Full record

ArticleJournal of medical case reports2022

Aplastic anemia: a new complication in the recent mysterious hepatitis outbreak among children worldwide: two case reports.

Ali Ghanei-Shahmirzadi, Hamid Reihani, Ali Abbasi-Kashkooli, Fereshteh Karbasian, Seyyed Bozorgmehr Hedayati, Mohammadreza Bordbar, Maryam Ataollahi, Seyed Mohsen Dehghani, Bita Geramizadeh

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In one paragraph

Article in Journal of medical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ali Ghanei-ShahmirzadiStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamid ReihaniStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali Abbasi-KashkooliStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Fereshteh KarbasianDepartment of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran. Karbasian.md@gmail.com.
Seyyed Bozorgmehr HedayatiHematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammadreza BordbarHematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam AtaollahiGastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mohsen DehghaniGastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Bita GeramizadehShiraz Transplant Research Center (STRC), Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, an unknown hepatitis outbreak among children has concerned many individuals worldwide. These cases are frequently reported, mainly from Europe and other countries. In this study, we present two similar patients, who, to the best of our knowledge, are the first cases reported in the Middle East (Shiraz, Fars Province, Iran). Unlike in similar cases reported up until 30 April 2022, our patients' hepatitis eventually resulted in aplastic anemia. CASE PRESENTATION: In this study, we present cases of two Iranian boys aged 13 and 8 years with hepatitis of unknown origin who developed aplastic anemia in the course of hospitalization.

conclusionsHepatitis-associated aplastic anemia is a well-known immune-mediated form of aplastic anemia that we detected in our patients and treated with immunosuppressive therapy. One patient established a satisfactory response to the treatment, but unfortunately, the other was declared brain dead.

Indexed as

Anemia, AplasticHepatitisChildDisease OutbreaksHumansImmunosuppression TherapyIranMaleAplastic anemiaHepatitisHepatitis-associated aplastic anemiaOutbreak

Identifiers

PMID36329514
PMCPMC9632563
OpenAlexW4308436159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.