ArticleBMC veterinary research2022
Isolation and identification of the broad-spectrum high-efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens.
Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Pooled it
- Isolation and identification of a chicken-derived Salmonella phage VB-SalS-XND03, Its biological characteristics and application effect against Salmonella infection in chicks.Poultry science · 2026Article
- A microbial consortium constructed with gut microbes of Chinese native chicken breeds protects chicks against Salmonella infection.Journal of animal science and biotechnology · 2026Article
- Bacteriophages as Potential Sustainable Alternatives to Antibiotics for ControllingAntibiotics (Basel, Switzerland) · 2026Review
- The amplification of bacteriophages using Salmonella YB1 as a host and its therapeutic efficacy against salmonellosis in broilers.Poultry science · 2026Article
- Characterization and therapeutic evaluation of a novel phage S18-3 targeting poultry-derived Enterobacter hormaechei infection in mice.BMC veterinary research · 2026Article
- Isolation and characterization of a lytic bacteriophage against Staphylococcus aureus.BMC veterinary research · 2026Article
- An LPS-Deficient vaccine candidate with steD deletion confers enhanced protection against homologous and heterologous Salmonella.BMC veterinary research · 2025Article
- Infection and resistance mechanisms of phage vB_VpM-PP270 iniScience · 2025Article
- Optimizing phage therapy for Salmonella Pullorum: dosage, timing, and pharmacokinetics define treatment efficacy in SPF chickens.Poultry science · 2025Article
- A Novel LyticFoods (Basel, Switzerland) · 2025Article
- Isolation and characterization of a novel bacteriophage ST1749 and its effectiveness against Vibrio parahaemolyticus and Salmonella spp.Virus research · 2025Article
- Characterization of Newly IsolatedMicroorganisms · 2025Article
- Characterization of a new lytic bacteriophage vB_RanS_GDF21 and its endolysin LysGDF21 with antimicrobial activity againstFrontiers in microbiology · 2025Article
- Correction: Isolation and identification of the broad‑spectrum high‑efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens.BMC veterinary research · 2024Article
- Article
- Evaluation of lyophilized bacteriophage cocktail efficiency against multidrug-resistant Salmonella in broiler chickens.BMC microbiology · 2024Article
- Unveiling the synergistic potency of chlorhexidine and azithromycin in combined action.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Phenotypic characterization and genomic analysis of a Salmonella phage L223 for biocontrol of Salmonella spp. in poultry.Scientific reports · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalmonella infection in livestock and poultry causes salmonellosis, and is mainly treated using antibiotics. However, the misuse use of antibiotics often triggers the emergence of multi-drug-resistant Salmonella strains. Currently, Salmonella phages is safe and effective against Salmonella, serving as the best drug of choice. This study involved 16 Salmonella bacteriophages separated and purified from the sewage and the feces of the broiler farm. A phage, vB_SalP_LDW16, was selected based on the phage host range test. The phage vB_SalP_LDW16 was characterized by the double-layer plate method and transmission electron microscopy. Furthermore, the clinical therapeutic effect of phage vB_SalP_LDW16 was verified by using the pathogenic Salmonella Enteritidis in the SPF chicken model.
resultsThe phage vB_SalP_LDW16 with a wide host range was identified to the family Siphoviridae and the order Caudoviridae, possess a double-stranded DNA and can lyse 88% (22/25) of Salmonella strains stored in the laboratory. Analysis of the biological characteristics, in addition, revealed the optimal multiplicity of infection (MOI) of vB_SalP_LDW16 to be 0.01 and the phage titer to be up to 3 × 10
conclusionsThe phage vB_SalP_LDW16 is a highly lytic phage with a wide host range, which can be potentially used for preventing and treating chicken salmonellosis, as an alternative or complementary antibiotic treatment in livestock farming.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.