Evidence map›Paper›PMID 36329492›Full record

ReviewJournal of neuroengineering and rehabilitation2022

Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.

Hui Ye, Jenna Hendee, Joyce Ruan, Alena Zhirova, Jayden Ye, Maria Dima

Open access · goldAbstract readReview
In one paragraph

Review in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Churning Better Transcranial Direct Current Stimulation Outcome with Accelerated Protocols: Understanding the Non-linear Dynamics through Metaplasticity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024
    Review
  10. Quasistatic approximation in neuromodulation.Journal of neural engineering · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hui YeDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA. hye1@luc.edu.
Jenna HendeeDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA.
Joyce RuanDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA.
Alena ZhirovaDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA.
Jayden YeDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA.
Maria DimaDepartment of Biology, Quinlan Life Sciences Education and Research Center, Loyola University Chicago, 1032 W. Sheridan Rd., Chicago, IL, 60660, USA.
Loyola University Chicago · US

Funding

Cellular Mechanisms Underlying State-Dependent Neural Inhibition with Magnetic StimulationR03NS130387 · NINDS · LOYOLA UNIVERSITY OF CHICAGO · PI YE, HUI · 2022 to 2022
$145k
NIH HHS R03NS130387NINDS NIH HHS R03 NS130387
6 · The paper itself

Abstract

Neuromodulation with electromagnetic stimulation is widely used for the control of abnormal neural activity, and has been proven to be a valuable alternative to pharmacological tools for the treatment of many neurological diseases. Tremendous efforts have been focused on the design of the stimulation apparatus (i.e., electrodes and magnetic coils) that delivers the electric current to the neural tissue, and the optimization of the stimulation parameters. Less attention has been given to the complicated, dynamic properties of the neurons, and their context-dependent impact on the stimulation effects. This review focuses on the neuronal factors that influence the outcomes of electromagnetic stimulation in neuromodulation. Evidence from multiple levels (tissue, cellular, and single ion channel) are reviewed. Properties of the neural elements and their dynamic changes play a significant role in the outcome of electromagnetic stimulation. This angle of understanding yields a comprehensive perspective of neural activity during electrical neuromodulation, and provides insights in the design and development of novel stimulation technology.

Indexed as

Nervous System DiseasesTranscranial Magnetic StimulationElectromagnetic PhenomenaHumansNeuronsDeep brain stimulation (DBS)DynamicsElectrical stimulationIon channelsNeuromodulationNeuronTranscranial magnetic stimulation (TMS)

Identifiers

PMID36329492
PMCPMC9632094
OpenAlexW4308496138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.