Evidence map›Paper›PMID 36329465›Full record

ArticleJournal of nanobiotechnology2022

Dual-targeting nanozyme for tumor activatable photo-chemodynamic theranostics.

Chaoyi Chen, Yuwen Chen, Lulu Zhang, Xuanhao Wang, Qingshuang Tang, Yan Luo, Yuan Wang, Cheng Ma, Xiaolong Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chaoyi ChenDepartment of Ultrasound, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, 100191, Beijing, China.
Yuwen ChenDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, 100084, Beijing, China.
Lulu ZhangDepartment of Ultrasound, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, 100191, Beijing, China.
Xuanhao WangDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, 100084, Beijing, China.
Qingshuang TangDepartment of Ultrasound, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, 100191, Beijing, China.
Yan LuoDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, 100084, Beijing, China.
Yuan WangDepartment of Ultrasound, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, 100191, Beijing, China.
Cheng MaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Tsinghua University, 100084, Beijing, China. cheng_ma@tsinghua.edu.cn.
Xiaolong LiangDepartment of Ultrasound, Peking University Third Hospital, 49 North Garden Rd., Haidian District Beijing, 100191, Beijing, China. xiaolong_liang@bjmu.edu.cn.

Funding

Peking University Third Hospital BYSYZD2019018, jyzc2018-02, and BYSY2015023
6 · The paper itself

Abstract

Tumor phototheranostics holds a great promise on account of its high spatiotemporal resolution, tumor-specificity, and noninvasiveness. However, physical limitation of light penetration and "always on" properties of conventional photothermal-conversion agents usually cause difficulty in accurate diagnosis and completely elimination of tumor. Meanwhile, nanozymes mediated Fenton reactions can well utilize the tumor microenvironment (TME) to generate hydroxyl radicals for chemodynamic therapy (CDT), but limited by the concentration of H

Indexed as

NanoparticlesNeoplasmsCell Line, TumorHumansHydrogen PeroxidePrecision MedicineTumor MicroenvironmentHydrogen PeroxideChemodynamic therapyFenton reactionNanozymePhotoacoustic imagingPhotothermal therapy

Identifiers

PMID36329465
PMCPMC9632160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.