Evidence map›Paper›PMID 36329374›Full record

ArticlePharmaceutical research2023

Quantum Cascade Laser Based Infrared Spectroscopy: A New Paradigm for Protein Secondary Structure Measurement.

Chunguang Jin, Amrish Patel, Jeremy Peters, Santosh Hodawadekar, Ravi Kalyanaraman

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chunguang JinGlobal Quality Analytical Science & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, 08901, USA. jerry.jin@bms.com.
Amrish PatelGlobal Quality Analytical Science & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, 08901, USA.
Jeremy PetersGlobal Quality Analytical Science & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, 08901, USA.
Santosh HodawadekarDRS Daylight Solutions, San Diego, California, 92127, USA.
Ravi KalyanaramanGlobal Quality Analytical Science & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, 08901, USA. ravi.kalyanaraman@bms.com.ORCID http://orcid.org/0000-0002-9421-9200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mid-infrared spectroscopy is one of the major analytical techniques employed for measurements of protein structure in solution. Traditional Fourier Transform-Infrared (FT-IR) measurement is limited by its blackbody light source that is inherently spatially incoherent and has low optical power output. This limitation is pronounced when working with proteins in aqueous solutions. Strong absorbance of water in protein amide I region 1600-1700 cm

Indexed as

Lasers, SemiconductorSerum Albumin, BovineAmidesSpectrophotometry, InfraredSpectroscopy, Fourier Transform InfraredWaterAmidesSerum Albumin, BovineWaterfusion proteininfrared spectroscopymonoclonal antibodypartial least squaresprotein secondary structurequantum cascade laser

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.