Evidence map›Paper›PMID 36329288›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

TSPO PET signal using [

Stefanie Quach, Adrien Holzgreve, Lena Kaiser, Marcus Unterrainer, Franziska J Dekorsy, Debie V Nelwan, Laura M Bartos, Sabrina V Kirchleitner, Jonathan Weller, Lorraine Weidner and 13 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  6. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
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  9. Review
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  11. Article
  12. Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Article
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 1 country.

Stefanie QuachDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lena KaiserDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Marcus UnterrainerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Franziska J DekorsyDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Debie V NelwanDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Laura M BartosDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Sabrina V KirchleitnerDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Jonathan WellerDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lorraine WeidnerDepartment of Neuropathology, Regensburg University Hospital, Regensburg, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Viktoria C RufCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Jochen HermsCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Sophia StöckleinDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Christian WetzelDepartment of Psychiatry and Psychotherapy, Molecular Neurosciences, University of Regensburg, Regensburg, Germany.
Markus J RiemenschneiderDepartment of Neuropathology, Regensburg University Hospital, Regensburg, Germany.
Louisa V BaumgartenDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Niklas ThonDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, Molecular Neurosciences, University of Regensburg, Regensburg, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Joerg-Christian TonnDepartment of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany. nathalie.albert@med.uni-muenchen.de.
LMU Klinikum · DELudwig-Maximilians-Universität München · DEUniversity Hospital Regensburg · DEUniversity of Regensburg · DEGerman Cancer Research Center · DEHeidelberg University · DE

Funding

Deutsche Forschungsgemeinschaft FOR-2858
6 · The paper itself

Abstract

purposeGlioma patients, especially recurrent glioma, suffer from a poor prognosis. While advances to classify glioma on a molecular level improved prognostication at initial diagnosis, markers to prognosticate survival in the recurrent situation are still needed. As 18 kDa translocator protein (TSPO) was previously reported to be associated with aggressive histopathological glioma features, we correlated the TSPO positron emission tomography (PET) signal using [

methodsIn patients with [

resultsEighty-eight consecutive patients were evaluated. TSPO tracer uptake correlated with tumor grade at recurrence (p < 0.05), with no significant differences in IDH-wild-type versus IDH-mutant tumors. Within the subgroup of IDH-mutant glioma (n = 46), patients with low SUV

conclusionOur data suggest that TSPO PET using [

Indexed as

Brain NeoplasmsGlioblastomaGliomaHumansNeoplasm Recurrence, LocalPositron-Emission TomographyReceptors, GABATyrosineReceptors, GABATSPO protein, humanTyrosine[18F]GE180 PETGliomaPrognostic biomarkerSurvivalTSPO

Identifiers

PMID36329288
PMCPMC9852133
OpenAlexW4308186704

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.