ArticlePediatric research2023
Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes: an exploratory study.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Temporal brain dynamics and fluid reasoning after extreme prematurity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cortical surface area, thalamic nuclei volume, and associations with neurocognitive functioning in 6-13-year-old children born late preterm and full term.medRxiv : the preprint server for health sciences · 2026Article
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants.Computer methods and programs in biomedicine · 2024Article
- Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.Pediatric research · 2024Article
- Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents.Psychiatry and clinical neurosciences · 2024Article
- Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.Brain structure & function · 2024Article
- Prenatal Exposure to Maternal Mood Entropy Is Associated With a Weakened and Inflexible Salience Network in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren born very preterm (VPT; <32 weeks' gestation) are at high risk of neurodevelopmental and behavioural difficulties associated with atypical brain maturation, including socio-emotional difficulties. The analysis of large-scale brain network dynamics during rest allows us to investigate brain functional connectivity and its association with behavioural outcomes.
methodsDynamic functional connectivity was extracted by using the innovation-driven co-activation patterns framework in VPT and full-term children aged 6-9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity (VPT, n = 28; full-term, n = 12). Multivariate analysis was used to explore potential biomarkers for socio-emotional difficulties in VPT children.
resultsThe spatial organisation of the 13 retrieved functional networks was comparable across groups. Dynamic features and lateralisation of network brain activity were also comparable for all brain networks. Multivariate analysis unveiled group differences in associations between dynamical functional connectivity parameters with socio-emotional abilities.
conclusionIn this exploratory study, the group differences observed might reflect reduced degrees of maturation of functional architecture in the VPT group in regard to socio-emotional abilities. Dynamic features of functional connectivity could represent relevant neuroimaging markers and inform on potential mechanisms through which preterm birth leads to neurodevelopmental and behavioural disorders. IMPACT: Spatial organisation of the retrieved resting-state networks was comparable between school-aged very preterm and full-term children. Dynamic features and lateralisation of network brain activity were also comparable across groups. Multivariate pattern analysis revealed different patterns of association between dynamical functional connectivity parameters and socio-emotional abilities in the very preterm and full-term groups. Findings suggest a reduced degree of maturation of the functional architecture in the very preterm group in association with socio-emotional abilities.
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