ArticleEye (London, England)2023
Incidence and risk factors for glaucoma development and progression after corneal transplantation.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- A systematic review and network meta-analysis of surgical interventions for glaucoma following penetrating keratoplasty.Scientific reports · 2025Pooled it
- A Multimodal Measurement System for Quantifying Time-Dependent Suture Tension Relaxation and Wound Closure Strength.Annals of biomedical engineering · 2026Article
- Association between systemic inflammatory response index and glaucoma incidence from 2005 to 2008.Frontiers in medicine · 2025Article
- A Pilot Study on Predicting Ocular Hypertension in Chinese Patients Undergoing Femtosecond Laser-Assisted Penetrating Keratoplasty.International journal of medical sciences · 2025Article
- Risk Factors for Glaucoma and Ocular Hypertension and Post-Transplant Complications in Keratoconus: A Multivariable Analysis.Journal of clinical medicine · 2024Article
- Glaucoma surgery success and corneal graft survival in patients with prior corneal transplantation: A retrospective cohort study.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Short-Term Outcomes of PreserFlo for Secondary Glaucoma after Combined Descemet Stripping Automated Endothelial Keratoplasty and Artificial Iris-Intraocular Lens Implantation: A Case Report.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the cumulative incidence and risk factors for glaucoma development and progression within 1-2 years following corneal transplant surgery.
designRetrospective cohort study.
methodsPatients undergoing penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping endothelial keratoplasty (DSEK), Descemet membrane endothelial keratoplasty (DMEK), Boston keratoprosthesis type I (KPro) implantation, or endothelial keratoplasty (DSEK or DMEK) under previous PK (EK under previous PK) at one academic institution with at least 1 year of follow-up were included. Primary outcome measures were cumulative incidence of glaucoma development and progression after corneal transplant, in patients without and with preoperative glaucoma, respectively. Risk factors for glaucoma development and progression were also assessed.
resultsFour hundred and thirty-one eyes of 431 patients undergoing PK (113), DALK (17), DSEK (71), DMEK (168), KPro (35) and EK under previous PK (27) with a mean follow-up of 22.9 months were analyzed. The 1-year cumulative incidence for glaucoma development and progression was 28.0% and 17.8% in patients without and with preoperative glaucoma, respectively. In a Cox proportional hazards analysis, DSEK surgery, KPro implantation, average intraocular pressure (IOP) through follow-up and postoperative IOP spikes of ≥30 mmHg were each independently associated with glaucoma development or progression (p < 0.04 for all).
conclusionsA significant proportion of patients developed glaucoma or exhibited glaucoma progression within 1 year after corneal transplantation. Patient selection for DSEK may partly explain the higher risk for glaucoma in these patients. Postoperative IOP spikes should be minimized and may indicate the need for co-management with a glaucoma specialist.
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