ArticleEye (London, England)2023
UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Oculomics and the NHS: A UK opportunity to translate eye-derived biomarkers into population health.Eye (London, England) · 2026Article
- Ethnicity-Stratified Normative Retinal Vascular Features from the UK Biobank Using Deep Learning.Ophthalmology science · 2026Article
- Cohort Profile: The North East London Diabetes Study (NELDS).International journal of epidemiology · 2026Article
- Imaging-based organ-specific aging clock predicts human diseases and mortality.NPJ digital medicine · 2026Article
- Neuroretinal and Photoreceptor Layer Thickness Reduction Associates With Impaired Cardiovascular Health: The UK Biobank Study.Investigative ophthalmology & visual science · 2026Article
- Article
- Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice.Science translational medicine · 2025Article
- Genetic insights into foveal morphology and its associations with pigmentation and age-related macular degeneration.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.Nature communications · 2025Article
- Associations of Metabolically Healthy Obesity and Retinal Age Gap.Translational vision science & technology · 2024Article
- RBAD: A Dataset and Benchmark for Retinal Vessels Branching Angle Detection.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank.Investigative ophthalmology & visual science · 2024Article
- Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline.bioRxiv : the preprint server for biology · 2024Article
- Retinal morphology across the menstrual cycle: insights from the UK Biobank.npj women's health · 2024Article
- Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.JAMA ophthalmology · 2023Article
- Reply.Ophthalmology scienceArticle
- Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration.Ophthalmology scienceArticle
- Highly Accurate and Precise Automated Cup-to-Disc Ratio Quantification for Glaucoma Screening.Ophthalmology scienceArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
BACKGROUND/
objectivesThis study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009-2010, and to characterise individuals with retinal features suggestive of age-related macular degeneration (AMD), glaucoma and retinopathy.
methodsNon-mydriatic colour fundus photographs and macular optical coherence tomography (OCT) scans were manually graded by Central Administrative Research Facility certified graders and quality assured by clinicians of the Network of Ophthalmic Reading Centres UK. Captured retinal features included those associated with AMD (≥1 drusen, pigmentary changes, geographic atrophy or exudative AMD; either imaging modality), glaucoma (≥0.7 cup-disc ratio, ≥0.2 cup-disc ratio difference between eyes, other abnormal disc features; photographs only) and retinopathy (characteristic features of diabetic retinopathy with or without microaneurysms; either imaging modality). Suspected cases of these conditions were characterised with reference to diagnostic records, physical and biochemical measurements.
resultsAmong 68,514 UKBB participants who underwent retinal imaging, the mean age was 57.3 years (standard deviation 8.2), 45.7% were men and 90.6% were of White ethnicity. A total of 64,367 participants had gradable colour fundus photographs and 68,281 had gradable OCT scans in at least one eye. Retinal features suggestive of AMD and glaucoma were identified in 15,176 and 2184 participants, of whom 125 (0.8%) and 188 (8.6%), respectively, had a recorded diagnosis. Of 264 participants identified to have retinopathy with microaneurysms, 251 (95.1%) had either diabetes or hypertension.
conclusionsThis dataset represents a valuable addition to what is currently available in UKBB, providing important insights to both ocular and systemic health.
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