ArticleCommunications biology2022
A short-term memory trace persists for days in the mouse hippocampus.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Unforgettable forgotten memories.Nature neuroscience · 2026Article
- Origin of visual experience-dependent theta oscillations.Current biology : CB · 2025Article
- Formation of long-term memory without short-term memory revealed by CaMKII inhibition.Nature neuroscience · 2025Article
- Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.PloS one · 2025Article
- Sleep and quiet wakefulness signify an idling brain hub for creative insights.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Sex and the facilitation of cued fear by prior contextual fear conditioning in rats.bioRxiv : the preprint server for biology · 2024Article
- Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease.Progress in neurobiology · 2024Review
- Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.Molecular brain · 2023Article
- Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.Biology open · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active recall of short-term memory (STM) is known to last for a few hours, but whether STM has long-term functions is unknown. Here we show that STM can be optogenetically retrieved at a time point during which natural recall is not possible, uncovering the long-term existence of an STM engram. Moreover, re-training within 3 days led to natural long-term recall, indicating facilitated consolidation. Inhibiting offline CA1 activity during non-rapid eye movement (NREM) sleep, N-methyl-D-aspartate receptor (NMDAR) activity, or protein synthesis after first exposure to the STM-forming event impaired the future re-exposure-facilitated consolidation, which highlights a role of protein synthesis, NMDAR and NREM sleep in the long-term storage of an STM trace. These results provide evidence that STM is not completely lost within hours and demonstrates a possible two-step STM consolidation, first long-term storage as a behaviorally inactive engram, then transformation into an active state by recurrence within 3 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.