ArticleNature communications2022
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- PCK2 Promotes Ribosome Biogenesis in Cervical Cancer Cells via Interaction with hnRNPK.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer.Scientific reports · 2026Article
- RNA-binding proteins in aging and age-related diseases: roles, mechanisms, and a large language model analysis.Biogerontology · 2026Review
- Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review).Molecular medicine reports · 2026Review
- A tRNA-derived fragment tRF3019a promotes LUAD metastasis by stabilizing hnRNPK and enhancing MYH11 expression.Cellular & molecular biology letters · 2026Article
- CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Discovery of Small Molecules That Inhibit MYC mRNA Translation Through hnRNPK and Induction of Stress Granule-Mediated mRNA Relocalization.International journal of molecular sciences · 2025Article
- A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL.Scientific reports · 2025Article
- Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy.Cancer cell · 2025Review
- lncRNAs: the unexpected link between protein synthesis and cancer adaptation.Molecular cancer · 2025Review
- Regulation of HNRNP family by post-translational modifications in cancer.Cell death discovery · 2024Review
- Role of LMO7 in cancer (Review).Oncology reports · 2024Review
- SHP2 mutations promote glycolysis and inhibit apoptosis via PKM2/hnRNPK signaling in colorectal cancer.iScience · 2024Article
- Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression.Journal of experimental & clinical cancer research : CR · 2024Article
- A novel and independent survival prognostic model for OSCC: the functions and prognostic values of RNA-binding proteins.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
Corrections and comments
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Authors and funding
24 authors at 8 institutions in 2 countries.
Bartosz MuchaDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Shuo QieDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0002-3481-3582
Sagar BajpaiDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Vincenzo TaralloDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID 0000-0001-8158-1326
J Nathaniel DiehlCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Frank TedeschiDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Gao ZhouCenter for RNA Science and Therapeutics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Zhaofeng GaoDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44016, USA.
Samuel FlashnerDivision of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.ORCID 0000-0001-9796-0515
Andres J Klein-SzantoHistopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.ORCID 0000-0002-5533-9402
Hanina HibshooshDivision of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Shimonosono MasatakaDivision of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Olga S ChajewskiDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Ireneusz MajsterekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, 60 Narutowicza St. 90-136, Lodz, Poland.ORCID 0000-0001-6231-3334
Dariusz PytelDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Maria HatzoglouDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44016, USA.ORCID 0000-0003-2037-1231
Channing J DerCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hiroshi NakagawaDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Adam J BassDivision of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.ORCID 0000-0002-8193-4758
Kwok-Kin WongDivision of Hematology and Medical Oncology, Perlmutter Cancer Center, New York University, New York, NY, 10016, USA.ORCID 0000-0001-6323-235X
Serge Y FuchsDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0002-0136-5103
Anil K RustgiDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Eckhard JankowskyDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
J Alan DiehlDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA. jad283@case.edu.ORCID 0000-0001-9854-5049
Case Western Reserve University · USColumbia University Irving Medical Center · USUniversity of North Carolina at Chapel Hill · USMedical University of South Carolina · USFox Chase Cancer Center · USMedical University of Lodz · PLNew York University · USUniversity of Pennsylvania · US
Funding
Transformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2003 to 2023
$31.7MRegulation of Gene Expression During StressR01DK053307 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 1998 to 2021
$9.6MThe Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2MTranslational Control by NutrientsR01DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MARIA HATZOGLOU · 2002 to 2026
$6.3MTargeting undruggable RAS for cancer treatmentR35CA232113 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 2018 to 2024
$6.3MEnzymes and enzyme complexes in RNA metabolismR35GM118088 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI JANKOWSKY, ECKHARD · 2016 to 2022
$4.3MNCI NIH HHS P01 CA098101NCI NIH HHS R35 CA232113NIDDK NIH HHS P30 DK132710NIDDK NIH HHS R01 DK053307NIDDK NIH HHS R01 DK060596NIGMS NIH HHS R35 GM118088
Abstract
Heterogeneous Nuclear Ribonucleoprotein K (hnRNPK) is a multifunctional RNA binding protein (RBP) localized in the nucleus and the cytoplasm. Abnormal cytoplasmic enrichment observed in solid tumors often correlates with poor clinical outcome. The mechanism of cytoplasmic redistribution and ensuing functional role of cytoplasmic hnRNPK remain unclear. Here we demonstrate that the SCF
Indexed as
CarcinogenesisHeterogeneous-Nuclear Ribonucleoprotein KHumansOncogenesRNA-Binding ProteinsRNA, MessengerUbiquitinationHeterogeneous-Nuclear Ribonucleoprotein KHNRNPK protein, humanRNA-Binding ProteinsRNA, Messenger
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