ArticleNature communications2022
Multimodal analysis demonstrating the shaping of functional gradients in the marmoset brain.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- The cellular correlates and adolescent reorganisation of cortical myelination networks in the common marmoset.Communications biology · 2026Article
- An anatomical and connectivity atlas of the tree shrew brain to bridge rodent and primate neuroanatomy.PLoS biology · 2026Article
- Emotion regulation success involves systematic gradient-based reconfigurations of large-scale activation patterns in the human brain.PLoS biology · 2026Article
- Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.Nature communications · 2026Article
- Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.Nature communications · 2025Article
- Large-scale brain mediation network based on resting-state functional MRI.Communications biology · 2025Article
- Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.Neuroinformatics · 2024Review
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Human connectome topology directs cortical traveling waves and shapes frequency gradients.Nature communications · 2024Article
- Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets.Nature communications · 2024Article
- Structural lesions and transcriptomic specializations shape gradient perturbations in Wilson disease.Brain communications · 2024Article
- Mapping and comparing fMRI connectivity networks across species.Communications biology · 2023Review
- Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice.Nature communications · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of functional gradients introduce a new perspective in understanding the cortical spectrum of intrinsic dynamics, as it captures major axes of functional connectivity in low-dimensional space. However, how functional gradients arise and dynamically vary remains poorly understood. In this study, we investigated the biological basis of functional gradients using awake resting-state fMRI, retrograde tracing and gene expression datasets in marmosets. We found functional gradients in marmosets showed a sensorimotor-to-visual principal gradient followed by a unimodal-to-multimodal gradient, resembling functional gradients in human children. Although strongly constrained by structural wirings, functional gradients were dynamically modulated by arousal levels. Utilizing a reduced model, we uncovered opposing effects on gradient dynamics by structural connectivity (inverted U-shape) and neuromodulatory input (U-shape) with arousal fluctuations, and dissected the contribution of individual neuromodulatory receptors. This study provides insights into biological basis of functional gradients by revealing the interaction between structural connectivity and ascending neuromodulatory system.
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