ArticleNature communications2022
Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reward history guides focal attention in whisker somatosensory cortex.Nature communications · 2025Article
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Article
- Sensory experience steers representational drift in mouse visual cortex.Nature communications · 2024Article
- Reward history guides focal attention in whisker somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Degraded tactile coding in the Cntnap2 mouse model of autism.Cell reports · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.Current biology : CB · 2024Article
- A mechanism for deviance detection and contextual routing in the thalamus: a review and theoretical proposal.Frontiers in neuroscience · 2024Article
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
- VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals.Current biology : CB · 2023Article
- Learning in a sensory cortical microstimulation task is associated with elevated representational stability.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discrimination. Neurons tuned for columnar (CW) and non-columnar (non-CW) whiskers were spatially intermixed, with co-tuned neurons forming local (20 µm) clusters. Whisker tuning was markedly unstable in expert mice, with 35-46% of pyramidal cells significantly shifting tuning over 5-18 days. Tuning instability was highly concentrated in non-CW tuned neurons, and thus was structured in the map. Instability of non-CW neurons was unchanged during chronic whisker paralysis and when mice discriminated individual whiskers, suggesting it is an inherent feature. Thus, L2/3 combines two distinct components: a stable columnar framework of CW-tuned cells that may promote spatial perceptual stability, plus an intermixed, non-columnar surround with highly unstable tuning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.