Evidence map›Paper›PMID 36328855›Full record

ArticleAnnals of emergency medicine2023

Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision.

Christopher W Jones, Xinming An, Yinyao Ji, Mochuan Liu, Donglin Zeng, Stacey L House, Francesca L Beaudoin, Jennifer S Stevens, Thomas C Neylan, Gari D Clifford and 44 more

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Article in Annals of emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

54 authors.

Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ.
Xinming AnDepartment of Anesthesiology, Department of Psychiatry, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Yinyao JiDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.
Mochuan LiuDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.
Donglin ZengDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St Louis, MO.
Francesca L BeaudoinDepartment of Emergency Medicine and Department of Health Services, Policy, and Practice, The Alpert Medical School of Brown University, Rhode Island Hospital and The Miriam Hospital, Providence, RI.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
Thomas C NeylanDepartment of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine and Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI.
Sarah D LinnstaedtDepartment of Anesthesiology, Department of Psychiatry, Institute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Laura T GermineInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA; The Many Brains Project, Belmont, MA; Department of Psychiatry, Harvard Medical School, Boston, MA.
Kenneth A BollenDepartment of Psychology and Neuroscience and Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School, Boston, MA; Department of Psychiatry, McLean Hospital, Belmont, MA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN.
Phyllis L HendryDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL; Department of Emergency Medicine, University of Cincinnati College of Medicine, and College of Nursing, University of Cincinnati, Cincinnati, OH.
Brittany E PunchesDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL.
Michael S LyonsCollege of Nursing, University of Cincinnati, Cincinnati, OH.
Michael C KurzDepartment of Emergency Medicine, Division of Acute Care Surgery, Department of Surgery, University of Alabama School of Medicine, and Center for Injury Science, University of Alabama at Birmingham, Birmingham, AL.
Robert A SworDepartment of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI.
Meghan E McGrathDepartment of Emergency Medicine, Boston Medical Center, Boston, MA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA; Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Pennsylvania, PA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Pennsylvania, PA; Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA.
Mark J SeamonDivision of Traumatology, Department of Surgery, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Pennsylvania, PA.
Elizabeth M DatnerDepartment of Emergency Medicine, Einstein Healthcare Network, and the Sidney Kimmel Medical College, Thomas Jefferson University, Pennsylvania, PA.
Erica HarrisEinstein Medical Center, Philadelphia, PA.
Anna M ChangDepartment of Emergency Medicine, Jefferson University Hospitals, Pennsylvania, PA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St John Hospital, Detroit, MI.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA.
Robert M DomeierDepartment of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, MI.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School, University of Texas Health, Houston, TX.
Leon D SanchezDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA; Department of Emergency Medicine, Harvard Medical School, Boston, MA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St Louis, St Louis, MO.
Mark W MillerNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, and Department of Psychiatry, Boston University School of Medicine, Boston, MA; Clinical Neurosciences Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT.
Robert H PietrzakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT.
Jutta JoormannDepartment of Psychology, Yale School of Medicine, New Haven, CT.
Deanna M BarchDepartment of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO.
Diego A PizzagalliDepartment of Psychiatry, Harvard Medical School, Boston, MA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA.
John F SheridanDepartment of Biosciences, and the Institute for Behavioral Medicine Research, OSU Wexner Medical Center, Columbus, OH.
Jordan W SmollerDepartment of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.
Steven E HarteDepartment of Anesthesiology, and Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI.
James M ElliottKolling Institute of Medical Research, University of Sydney, St Leonards, and Faculty of Medicine and Health, University of Sydney, Northern Sydney Local Health District, New South Wales, Australia, and Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Karestan C KoenenDepartment of Epidemiology, Harvard T H Chan School of Public Health, Harvard University, Boston, MA.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, MA; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA.
Samuel A McLeanDepartments of Emergency Medicine and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: smclean@aims.unc.edu.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Early Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4M
Neuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6M
MRI and machine learning to improve early prognosis and clinical management after spinal cord injuryR03HD094577 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2019 to 2020
$195k
SOCIAL SUPPORT OF CAREGIVERS FOR DEMENTIA PATIENTSF33AG005654 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI SOKOLOVSKY, JAY H · 1994 to 1994
–
NIA NIH HHS F33 AG005654NICHD NIH HHS R01 HD079076NICHD NIH HHS R03 HD094577NIMH NIH HHS R01 MH095809NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

STUDY

objectiveTo derive and initially validate a brief bedside clinical decision support tool that identifies emergency department (ED) patients at high risk of substantial, persistent posttraumatic stress symptoms after a motor vehicle collision.

methodsDerivation (n=1,282, 19 ED sites) and validation (n=282, 11 separate ED sites) data were obtained from adults prospectively enrolled in the Advancing Understanding of RecOvery afteR traumA study who were discharged from the ED after motor vehicle collision-related trauma. The primary outcome was substantial posttraumatic stress symptoms at 3 months (Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders-5 ≥38). Logistic regression derivation models were evaluated for discriminative ability using the area under the curve and the accuracy of predicted risk probabilities (Brier score). Candidate posttraumatic stress predictors assessed in these models (n=265) spanned a range of sociodemographic, baseline health, peritraumatic, and mechanistic domains. The final model selection was based on performance and ease of administration.

resultsSignificant 3-month posttraumatic stress symptoms were common in the derivation (27%) and validation (26%) cohort. The area under the curve and Brier score of the final 8-question tool were 0.82 and 0.14 in the derivation cohort and 0.76 and 0.17 in the validation cohort.

conclusionThis simple 8-question tool demonstrates promise to risk-stratify individuals with substantial posttraumatic stress symptoms who are discharged to home after a motor vehicle collision. Both external validation of this instrument, and work to further develop more accurate tools, are needed. Such tools might benefit public health by enabling the conduct of preventive intervention trials and assisting the growing number of EDs that provide services to trauma survivors aimed at promoting psychological recovery.

Indexed as

Stress Disorders, Post-TraumaticAccidents, TrafficAdultEmergency Service, HospitalHumansMotor Vehicles

Identifiers

PMID36328855
PMCPMC11181458

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.