ArticleJournal of advanced research2022
Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation.
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Identification of an Optimal Gyroid Microarchitecture of 3D-Printed Hydroxyapatite Bone Substitutes for Vertical Bone Augmentation and Osteoconduction.Biomolecules · 2026Article
- Optical Coherence Tomography, Stereomicroscopic, and Histological Aspects of Bone Regeneration on Rat Calvaria in the Presence of Bovine Xenograft or Titanium-Reinforced Hydroxyapatite.Journal of functional biomaterials · 2026Article
- Strategic Uniaxial Macropore Sizing for Honeycomb-Structured Scaffolds for Enhanced Bone Reconstruction in Segmental Bone Defects.ACS omega · 2025Article
- The Novel Osteopore® Wedge in Medial Opening Wedge High Tibial Osteotomy: A Technical Note.Cureus · 2025Article
- Bone Regeneration in Defects Created on Rat Calvaria Grafted with Porcine Xenograft and Synthetic Hydroxyapatite Reinforced with Titanium Particles-A Microscopic and Histological Study.Journal of functional biomaterials · 2025Article
- Guidance on the assessment of the functionality of biomaterials for periodontal tissue regeneration: Methodologies and testing procedures.Dental materials : official publication of the Academy of Dental Materials · 2025Review
- Bone augmentation using bioresorbable mesh domes containing bone graft granules.Journal of materials science. Materials in medicine · 2024Article
- Carbonate Apatite Honeycomb Scaffold-Based Drug Delivery System for Repairing Osteoporotic Bone Defects.ACS applied materials & interfaces · 2024Article
- In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.Scientific reports · 2024Article
- TPMS Microarchitectures for Vertical Bone Augmentation and Osteoconduction: An In Vivo Study.Materials (Basel, Switzerland) · 2024Article
- Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels.Materials (Basel, Switzerland) · 2023Article
- Mussel-inspired cortical bone-adherent bioactive composite hydrogels promote bone augmentation through sequential regulation of endochondral ossification.Materials today. Bio · 2023Article
- Three-Dimensional Printing of Polycaprolactone/Nano-Hydroxyapatite Composite Scaffolds with a Pore Size of 300/500 µm is Histocompatible and Promotes Osteogenesis Using Rabbit Cortical Bone Marrow Stem Cells.Annals of transplantation · 2023Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Effectiveness of biomechanically stable pergola-like additively manufactured scaffold for extraskeletal vertical bone augmentation.Frontiers in bioengineering and biotechnology · 2023Article
- Article
- Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration.Computational and structural biotechnology journal · 2023Article
- Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation.Bioengineering (Basel, Switzerland) · 2022Article
- Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System.ACS nano · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCases of intractable dental implant require vertical bone augmentation; however, the predicted bone height and volume are difficult to obtain. In vertical bone augmentation, the contact surface between the scaffold and the bone is limited to the bottom face of the scaffold. Furthermore, the strength decrease caused by scaffold resorption leads to collapse of the augmented site, leading to a decrease in the bone volume and height.
objectivesTo promote bone ingrowth, we fabricated carbonate apatite (i.e., bone mineral) honeycomb (HC) scaffolds with uniaxial channels vertically penetrating the scaffold. Furthermore, we controlled the scaffold resorption rate, eventually the endurability for compression, and the bone height and volume by controlling the strut thickness.
methodsThe channel aperture was controlled to be 230-260 μm to promote bone ingrowth. Furthermore, the strut thicknesses of the HC scaffolds were adjusted to 100, 200, and 300 μm to control the scaffold resorption; these scaffolds were designated as HC100, HC200, and HC300, respectively.
resultsAt 4 weeks post-implantation on rabbit calvarium, all scaffolds had already vertically augmented new bone close to the top surface of the scaffold. In the following 8 weeks, the height and amount of new bone in all scaffolds increased. Notably, HC300 was resorbed synchronously with new bone formation, allowing it to endure the compression from the fasciae for 12 weeks post-implantation. Furthermore, HC300 formed larger-diameter blood vessels than those of HC100 and HC200.
conclusionThe HC scaffolds surpassed the various combined scaffolds and growth factors or stem cells in the ability for vertical bone augmentation. Thus, the HC structure is inherently suitable for vertical bone augmentation. Notably, the HC scaffolds with 300-μm-thick struts enhanced both new bone formation and angiogenesis. This study revealed a structurally suitable design for achieving an outstanding outcome in vertical bone augmentation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.