ArticleJACC. Heart failure2022
Risks of Depression and Suicide After Diagnosis With Heart Failure: A National Cohort Study.
Article in JACC. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Heart failure and suicide mortality and suicide attempts: a systematic review and meta-analysis of cohort studies.Frontiers in cardiovascular medicine · 2026Pooled it
- Assessing suicide risk in patients with heart failure: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Activation of the nucleus nuclear factor erythroid 2-related factor 2ghrelin/growth hormone secretagogue receptor 1a signaling by Yueju pill confers cardioprotective and antidepressant effects.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Suicide risks associated with cardiovascular disease in persons with alcohol use disorder.Annals of epidemiology · 2026Article
- Reduced serum adiponectin and exercise predict depression in chronic heart failure patients and affect depressive-like behaviors in a mouse model.Frontiers in physiology · 2026Article
- Time to Death by Suicide in an Epidemiological Sample of Veterans With an Inpatient Hospitalization for Heart Failure.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Temporal trends in mortality related to heart failure and depression in the United States: 1999-2020.Global cardiology science & practice · 2025Article
- Article
- Association between vitamin A intake and depression among patients with heart failure.ESC heart failure · 2024Article
- Suicidal behaviour among patients with congestive cardiac failure in a Nigerian teaching hospital.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- One-year incidence of depression, anxiety, or stress disorders following a first-time heart failure diagnosis: A Danish nationwide registry-based study.American heart journal plus : cardiology research and practice · 2023Article
- Safety and effects of a home-based Tai Chi exercise rehabilitation program in patients with chronic heart failure: study protocol for a randomized controlled trial.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHeart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear.
objectivesIn this study, the authors sought to determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort.
methodsA national cohort study was conducted of all 154,572 persons diagnosed with HF at ages 18-75 years during 2002-2017 in Sweden and 1,545,720 age- and sex-matched population-based control subjects who were followed up for major depression and suicide ascertained from nationwide inpatient, outpatient, and death records through 2018. Poisson regression was used to compute incidence rate ratios (IRRs) while adjusting for sociodemographic factors and comorbidities.
resultsHF was associated with increased risks of major depression and death by suicide in both men and women, with highest risks in the first 3 months, then declining to modest risks at ≥12 months after HF diagnosis. Within 3 months after HF diagnosis, adjusted IRRs for new-onset major depression were 3.34 (95% CI: 3.04-3.68) in men and 2.78 (95% CI: 2.51-3.09) in women, and for suicide death were 4.47 (95% CI: 2.62-7.62) in men and 2.82 (95% CI: 1.11-7.12) in women. These risks were elevated regardless of age at HF diagnosis. HF was associated with significantly more depression cases in women (P < 0.001).
conclusionsIn this large national cohort, HF was associated with substantially increased risks of depression and suicide in men and women, with highest risks occurring within 3 months after HF diagnosis. Men and women with HF need timely detection and treatment of depression and suicidality.
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