Evidence map›Paper›PMID 36328482›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2023

Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants.

Jialin Liu, Suzanne Banuvar, Marlos Viana, Elena Barengolts, Shao-Nong Chen, Guido F Pauli, Richard B van Breemen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jialin LiuLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Suzanne BanuvarLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Marlos VianaLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Elena BarengoltsLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Shao-Nong ChenLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Guido F PauliLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.).
Richard B van BreemenLinus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.) richard.vanbreemen@oregonstate.edu.ORCID 0000-0003-2016-0063
Oregon State University · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Van Breemen: Project 3; Botanical Dietary Supplements - Metabolism and Safety in Women (Van Breemen)P50AT000155 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 1999 to 2019
$30.4M
NCATS NIH HHS UL1 TR002003NCCIH NIH HHS P50 AT000155
6 · The paper itself

Abstract

Licorice, the roots and rhizomes of

Indexed as

Cytochrome P-450 CYP1A2GlycyrrhizaCaffeineCytochrome P-450 CYP2C9Cytochrome P-450 CYP2D6Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemDietary SupplementsFemaleGlycyrrhizic AcidHumansPlant ExtractsTolbutamideCaffeineCytochrome P-450 CYP1A2Cytochrome P-450 CYP2C9Cytochrome P-450 CYP2D6Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemGlycyrrhiza glabra extractGlycyrrhizic AcidPlant ExtractsTolbutamide

Identifiers

PMID36328482
PMCPMC9900865
OpenAlexW4308178999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.