Evidence map›Paper›PMID 36328469›Full record

ArticleTobacco control2022

Removal of mango-flavoured Juul pods created opportunity for adulterated mango Juul-compatible pods with altered chemical constituents.

Liam G Dell, Michelle K Page, Noel J Leigh, Maciej Lukasz Goniewicz

Abstract read
In one paragraph

Article in Tobacco control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liam G DellDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Michelle K PageDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0002-5962-8586
Noel J LeighDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0002-6850-9634
Maciej Lukasz GoniewiczDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA maciej.goniewicz@roswellpark.org.ORCID 0000-0001-6748-3068

Funding

WNY Center for Research on Flavored Tobacco Products (CRoFT)U54CA228110 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI OSSIP, DEBORAH J · 2018 to 2022
$19.8M
NCI NIH HHS U54 CA228110
6 · The paper itself

Abstract

introductionJuul is a leading electronic cigarette (e-cigarette) brand in the USA. By November 2019, Juul pre-emptively limited online and in-store sales of non-tobacco or menthol-flavoured pods ahead of impending flavour bans. Since this removal, sale of mango-flavoured Juul-compatible pods was introduced to the market by smaller companies. The aim of this study was to compare chemical constituents of original Juul mango pods with mango-flavoured Juul-compatible pods.

methodsJuul and 16 brands of Juul-compatible mango-flavoured pods were purchased online in May 2018 (original Juul) and November 2019 (Juul-compatible), after Juul voluntarily removed their flavoured pods from the market. Liquid was extracted from pods and analysed using chromatography and mass spectrometry methods for nicotine concentration, solvent ratios, nicotine salt identification, as well as flavouring identification and quantitation.

resultsJuul-compatible pods had a significantly lower average nicotine concentration compared with original Juul pod (42.8±8.9 vs 57.2±0.9 mg/mL, p<0.0001). Nicotine benzoate was used in original Juul pod and all Juul-compatible pods. The propylene glycol to vegetable glycerin volumetric ratio of Juul-compatible pods averaged 55:45, while the original Juul pod was 35:65 (p<0.0001). Total number of flavouring chemicals detected was significantly higher in Juul-compatible pods as compared with Juul (p<0.0001). In Juul-compatible pods, average concentrations of benzyl alcohol (fruity flavouring) were 0.8±1.3 mg/mL, approximately 27 times higher than in original Juul pod (p<0.0001).

conclusionsAdulterated Juul-compatible products may expose e-cigarette consumers to more chemical constituents at higher concentrations than previously found in the original product, despite similarity in product design.

Indexed as

Electronic Nicotine Delivery SystemsMangiferaTobacco ProductsVapingFlavoring AgentsHumansNicotinePropylene GlycolFlavoring AgentsNicotinePropylene GlycolElectronic nicotine delivery devicesNicotineNon-cigarette tobacco products

Identifiers

PMID36328469
PMCPMC9664127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.