Evidence map›Paper›PMID 36328200›Full record

ArticleAmerican journal of ophthalmology2023

Combining Optical Coherence Tomography and Optical Coherence Tomography Angiography Longitudinal Data for the Detection of Visual Field Progression in Glaucoma.

Alireza Kamalipour, Sasan Moghimi, Pooya Khosravi, Vahid Mohammadzadeh, Takashi Nishida, Eleonora Micheletti, Jo-Hsuan Wu, Golnoush Mahmoudinezhad, Elizabeth H F Li, Mark Christopher and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Alireza KamalipourFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Sasan MoghimiFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Pooya KhosraviSchool of Medicine (P.K.), University of California, Irvine, Irvine, California, USA.
Vahid MohammadzadehFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Takashi NishidaFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Eleonora MichelettiFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Jo-Hsuan WuFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Golnoush MahmoudinezhadFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Elizabeth H F LiFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Mark ChristopherFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Linda ZangwillFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Tara JavidiDepartment of Electrical and Computer Engineering (T.J.), University of California San Diego, La Jolla.
Robert N WeinrebFrom the Hamilton Glaucoma (A.K., S.M., V.M., T.N., E.M., J-H.W., G.M., E.H.F.L., M.C., L.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology. Electronic address: rweinreb@health.ucsd.edu.
He Eye Hospital · CNUniversity of California, Irvine · USUniversity of California San Diego · US

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Radha Ayyagari · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence TomographyR00EY030942 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTOPHER, MARK · 2023 to 2025
$747k
Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence TomographyK99EY030942 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTOPHER, MARK · 2020 to 2021
$235k
NEI NIH HHS K99 EY030942NEI NIH HHS P30 EY022589NEI NIH HHS R00 EY030942NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

purposeTo use longitudinal optical coherence tomography (OCT) and OCT angiography (OCTA) data to detect glaucomatous visual field (VF) progression with a supervised machine learning approach.

designProspective cohort study.

methodsOne hundred ten eyes of patients with suspected glaucoma (33.6%) and patients with glaucoma (66.4%) with a minimum of 5 24-2 VF tests and 3 optic nerve head and macula images over an average follow-up duration of 4.1 years were included. VF progression was defined using a composite measure including either a "likely progression event" on Guided Progression Analysis, a statistically significant negative slope of VF mean deviation or VF index, or a positive pointwise linear regression event. Feature-based gradient boosting classifiers were developed using different subsets of baseline and longitudinal OCT and OCTA summary parameters. The area under the receiver operating characteristic curve (AUROC) was used to compare the classification performance of different models.

resultsVF progression was detected in 28 eyes (25.5%). The model with combined baseline and longitudinal OCT and OCTA parameters at the global and hemifield levels had the best classification accuracy to detect VF progression (AUROC = 0.89). Models including combined OCT and OCTA parameters had higher classification accuracy compared with those with individual subsets of OCT or OCTA features alone. Including hemifield measurements significantly improved the models' classification accuracy compared with using global measurements alone. Including longitudinal rates of change of OCT and OCTA parameters (AUROCs = 0.80-0.89) considerably increased the classification accuracy of the models with baseline measurements alone (AUROCs = 0.60-0.63).

conclusionsLongitudinal OCTA measurements complement OCT-derived structural metrics for the evaluation of functional VF loss in patients with glaucoma.

Indexed as

GlaucomaVisual FieldsFluorescein AngiographyHumansIntraocular PressureProspective StudiesTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID36328200
PMCPMC11789620
OpenAlexW4307906295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.