ArticlePsychiatry investigation2022
Association of a History of Sleep Disorder With Risk of Mild Cognitive Impairment and Alzheimer's Disease Dementia.
Article in Psychiatry investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2025Pooled it
- Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.GeroScience · 2025Pooled it
- Association between sleep apnoea and risk of cognitive impairment and Alzheimer's disease: a meta-analysis of cohort-based studies.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Bloodwork-free Early Screening for Alzheimer's Disease via Comorbid Pattern Recognition in Electronic Health Records.Research square · 2026Article
- Development, validation, and visualization of a machine learning-based predictive model for depression risk in sleep disorder patients.BMC psychiatry · 2025Article
- Association Between Self-Reported Sleep Quality and Conversion From Mild Cognitive Impairment to Dementia: A Retrospective Cohort Study Using the English Longitudinal Study of Ageing.Brain and behavior · 2025Article
- Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case-control study.Alzheimer's research & therapy · 2025Article
- Neuroprotective potential of quercetin in Alzheimer's disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-β aggregation.Frontiers in pharmacology · 2025Article
- Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States.SAGE open medicine · 2025Article
- Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Impaired sleep is associated with tau deposition onJournal of the neurological sciences · 2024Article
- Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review.Frontiers in neuroscience · 2024Review
- Detection of Insomnia and Its Relationship with Cognitive Impairment, Depression, and Quality of Life in Older Community-Dwelling Mexicans.Diagnostics (Basel, Switzerland) · 2023Article
- Development of risk prediction model for cognitive impairment in patients with coronary heart disease: A study protocol for a prospective, cross-sectional analysis.Frontiers in cardiovascular medicine · 2022Article
- Sleep disturbances and their correlation with memory impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment.Journal of Alzheimer's disease reportsArticle
- Acupuncture for chronic insomnia with mild cognitive impairment: protocol for a randomized controlled trial.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe explored whether a history of sleep disorder affected a current diagnosis of cognitive impairment and clinical conversion in a non-demented elderly population.
methodsComprehensive clinical data collected as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI) was analyzed. A history of sleep disorder was recorded in the recent ADNI medical database. Standard clinical and neuropsychological tests were performed both at baseline and follow-up visit. Multiple logistic regression analysis was performed after adjusting for age, sex, education, apolipoprotein E ε4 status, vascular risk score, body mass index, Geriatric Depression Scale score, and use of sleeping pills.
resultsA total of 391 cognitively normal individuals, 303 with early mild cognitive impairment (MCI) and 364 with late MCI were included. Sleep disorder history was significantly associated with an increased risk of MCI but not with clinical conversion. A history of insomnia or obstructive sleep apnea (OSA) significantly increased the risk of MCI, but only an OSA history predicted progression to Alzheimer's disease (AD) dementia.
conclusionOur findings suggest that a sleep disorder history usefully aids early detection of cognitive impairment and emphasize that such sleep disorder, particularly OSA, is important as potential target for AD prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.