Evidence map›Paper›PMID 36327770›Full record

ArticleJournal of molecular and cellular cardiology2022

A transcriptomic atlas of drug-induced endothelial dysfunction in human endothelial cells.

Chengyi Tu, Yu Liu, Damon R Williams, Joseph C Wu

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells.bioRxiv : the preprint server for biology · 2026
    Article
  3. Proteasome inhibitor-associated thrombotic microangiopathy: a real-world retrospective and pharmacovigilance database analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chengyi TuStanford Cardiovascular Institute, Stanford University, CA, USA.
Yu LiuStanford Cardiovascular Institute, Stanford University, CA, USA.
Damon R WilliamsStanford Cardiovascular Institute, Stanford University, CA, USA.
Joseph C WuStanford Cardiovascular Institute, Stanford University, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA. Electronic address: joewu@stanford.edu.

Funding

Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCsR01HL141851 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$5.7M
Modeling Susceptibility to Chemotherapy-Induced Cardiotoxicity Using Human iPSCsR01HL123968 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS, WU, JOSEPH C. · 2014 to 2021
$4.8M
Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell MultiomicsR01HL163680 · NHLBI · STANFORD UNIVERSITY · PI RAJADAS, JAYAKUMAR, WONG, WING H. · 2022 to 2025
$2.5M
Consortium Led Evaluation of Integrated Human-Relevant Approaches to Identify Drug Induced Cardiovascular LiabilitiesU01FD006676 · FDA · HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE · PI PIERSON, JENNIFER B · 2019 to 2023
$1.8M
FDA HHS U01 FD006676NHLBI NIH HHS R01 HL123968NHLBI NIH HHS R01 HL141851NHLBI NIH HHS R01 HL163680
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endothelial CellsInduced Pluripotent Stem CellsCell LineEndothelium, VascularHumansTranscriptomeChemotherapyDrug safetyEndothelial cellsEndothelial dysfunctioniPSCsVascular injuryVascular toxicity

Identifiers

PMID36327770
PMCPMC10902208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.