ArticleEpilepsy & behavior : E&B2022
Invasive neuromodulation for epilepsy: Comparison of multiple approaches from a single center.
Article in Epilepsy & behavior : E&B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Neurostimulation in children with drug-resistant epilepsy: strategies in subcortical targeting and systematic review of the evidence.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Non-invasive neurostimulation for drug-resistant epilepsy: systematic review and meta-analysis of effectiveness, safety, and optimal stimulation parameters.Journal of neurology · 2025Pooled it
- Efficacy and safety of deep brain stimulation in drug resistance epilepsy: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- The comparison of DBS and RNS for adult drug-resistant epilepsy: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Optimizing stimulation parameters for anterior thalamic nuclei deep brain stimulation in epilepsy: A randomized crossover trial.Epilepsia · 2025Trial
- Drug-resistant epilepsy in an autosomal recessive copper metabolism disorder from SLC33A1 mutation.Epilepsy & behavior reports · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Clinician, patient, and carer views on neuromodulation for epilepsy: is there rationale for a randomised controlled trial of VNS vs. DBS?Brain & spine · 2026Article
- Predicting response to neuromodulation therapies in drug-resistant epilepsy using machine learning models: a meta-analysis and systematic review.Bioelectronic medicine · 2025Review
- Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: Protocol for a systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters.Systematic reviews · 2025Article
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- Epilepsy Surgery in the Last 10 Years: Advancements and Controversies.Epilepsy currents · 2025Review
- Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies.Epilepsia open · 2025Article
- On brain stimulation in epilepsy.Brain : a journal of neurology · 2025Review
- Effect of deep brain stimulation on the severity of seizures and the quality of life in patients with multifocal drug-resistant epilepsy in Iran: A pilot review of local experience.Epilepsy & behavior reports · 2025Article
- Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep.Brain communications · 2025Article
- Interictal short-term high-frequency cortical stimulation modulates epileptogenic zone and distributed network.Brain communications · 2025Article
- Thalamocortical network neuromodulation for epilepsy.Brain communications · 2025Article
- Intracranial Voltage Profiles from Untangled Human Deep Sources Reveal Multisource Composition and Source Allocation Bias.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDrug-resistant epilepsy (DRE) patients not amenable to epilepsy surgery can benefit from neurostimulation. Few data compare different neuromodulation strategies.
objectiveCompare five invasive neuromodulation strategies for the treatment of DRE: anterior thalamic nuclei deep brain stimulation (ANT-DBS), centromedian thalamic nuclei DBS (CM-DBS), responsive neurostimulation (RNS), chronic subthreshold stimulation (CSS), and vagus nerve stimulation (VNS).
methodsSingle center retrospective review and phone survey for patients implanted with invasive neuromodulation for 2004-2021.
resultsN = 159 (ANT-DBS = 38, CM-DBS = 19, RNS = 30, CSS = 32, VNS = 40). Total median seizure reduction (MSR) was 61 % for the entire cohort (IQR 5-90) and in descending order: CSS (85 %), CM-DBS (63 %), ANT-DBS (52 %), RNS (50 %), and VNS (50 %); p = 0.07. The responder rate was 60 % after a median follow-up time of 26 months. Seizure severity, life satisfaction, and quality of sleep were improved. Cortical stimulation (RNS and CSS) was associated with improved seizure reduction compared to subcortical stimulation (ANT-DBS, CM-DBS, and VNS) (67 % vs. 52 %). Effectiveness was similar for focal epilepsy vs. generalized epilepsy, closed-loop vs. open-loop stimulation, pediatric vs. adult cases, and high frequency (>100 Hz) vs. low frequency (<100 Hz) stimulation settings. Delivered charge per hour varied widely across approaches but was not correlated with improved seizure reduction.
conclusionsMultiple invasive neuromodulation approaches are available to treat DRE, but little evidence compares the approaches. This study used a uniform approach for single-center results and represents an effort to compare neuromodulation approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.