Evidence map›Paper›PMID 36327534›Full record

ArticleGait & posture2023

Functional connectivity of proximal and distal lower limb muscles and impact on gait variability in stroke.

Hyosok Lim, Brice Cleland, Sangeetha Madhavan

Open access · greenAbstract read
In one paragraph

Article in Gait & posture, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hyosok LimBrain Plasticity Laboratory, Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA; Graduate Program in Rehabilitation Sciences, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Brice ClelandBrain Plasticity Laboratory, Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA.
Sangeetha MadhavanBrain Plasticity Laboratory, Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: smadhava@uic.edu.
University of Illinois Chicago · USIllinois College · US

Funding

Cortical priming to optimize gait rehabilitation post strokeR01HD075777 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MADHAVAN, SANGEETHA · 2014 to 2024
$4.1M
NICHD NIH HHS R01 HD075777
6 · The paper itself

Abstract

backgroundHigher gait variability after stroke increases risk of falls and compromises safe community ambulation. Corticomotor connectivity plays an important role in walking after stroke, however, its relation to gait variability remains unknown. RESEARCH QUESTION: Do corticomotor characteristics of the proximal and distal lower limb muscles predict gait variability in individuals with chronic stroke?

methodsRetrospective analysis of data from 30 individuals with chronic stroke was conducted. Corticomotor characteristics were measured in the paretic and non-paretic tibialis anterior (TA, distal muscle) and rectus femoris (RF, proximal muscle) using transcranial magnetic stimulation. We calculated corticomotor excitability ratio of paretic TA and RF (CME

resultsCME SIGNIFICANCE: Corticomotor inputs to the proximal RF may be important for spatial gait variability, reflecting a compensatory role of RF in walking after stroke. Stroke survivors with relatively greater corticomotor input to the paretic RF may adopt compensatory strategy to enhance propulsion and achieve foot clearance, but it may also increase spatial gait variability, particularly when combined with impaired motor control of the paretic TA. These findings may provide novel rehabilitative targets to decrease gait variability and promote safe ambulation in individuals with stroke.

Indexed as

Motor CortexStrokeStroke RehabilitationGaitHumansLower ExtremityMuscle, SkeletalParesisRetrospective StudiesWalkingCorticomotor excitabilityGait variabilityStrokeTranscranial magnetic stimulationWalking

Identifiers

PMID36327534
PMCPMC9832343
OpenAlexW4307041067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.