ReviewThe Journal of clinical endocrinology and metabolism2023
Current Controversies in Low-Risk Differentiated Thyroid Cancer: Reducing Overtreatment in an Era of Overdiagnosis.
Review in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers, Part II: Follow-up Surveillance after Initial Treatment 2026.Endocrinology and metabolism (Seoul, Korea) · 2026Guideline
- Intraoperative neuromonitoring reduces vocal cord injury in open thyroid cancer surgery: results from a randomized controlled trial.Surgical endoscopy · 2026Trial
- Feasibility study on individualized management of postoperative patients with differentiated thyroid cancer based on internet and programming technology.Journal of cancer research and clinical oncology · 2023Trial
- Disparities in Active Surveillance of Papillary Thyroid Microcarcinomas.Annals of surgical oncology · 2026Article
- Elastography Enhances Diagnostic Accuracy of ACR TI-RADS in Thyroid Nodule Evaluation.The Journal of clinical endocrinology and metabolism · 2026Article
- ATA 2015-2025 risk stratification transition: prognostic significance of N1b disease in papillary thyroid carcinoma with limited nodal burden.The oncologist · 2026Article
- Predicting unfavorable response to initial radioactive iodine therapy in differentiated thyroid cancer: an explainable machine learning and survival analysis approach.Frontiers in endocrinology · 2026Article
- The predictive value of platelet parameters for the response to initialFrontiers in endocrinology · 2026Article
- Global epidemiology of thyroid cancer: trends in incidence, mortality, and DALYs from 1990 to 2021.Open medicine (Warsaw, Poland) · 2026Article
- Internal validation of a residual thyroid recurrence model after PTC.Frontiers in oncology · 2026Article
- Review
- The predictive value of thyroid hormone sensitivity parameters for cervical lymph node metastasis in patients with differentiated thyroid cancer.Annals of medicine · 2025Article
- Prognostic value of preablative stimulated thyroglobulin and its decline afterAnnals of medicine · 2025Article
- Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.Gland surgery · 2025Article
- Semaglutide Reprograms Macrophages via the GLP-1R/PPARG/ACSL1 Pathway to Suppress Papillary Thyroid Carcinoma Growth.The Journal of clinical endocrinology and metabolism · 2025Article
- Papillary Thyroid Carcinoma and Its Hormonal Effects in Women Following Surgical Removal.Cureus · 2025Review
- [Results of active surveillance of clinical progression in low-risk papillary thyroid microcarcinoma: a single center prospective cohort study].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Observational
- Use of Neck Ultrasound as Surveillance in Older Adults With Thyroid Cancer.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025Article
- Impact of thyroglobulin changes on clinical outcomes of differentiated thyroid cancer with biochemical incomplete response.Endocrine · 2025Article
- Landmark Studies in Differentiated Thyroid Cancer.Annals of surgical oncology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
contextLow-risk differentiated thyroid cancer (DTC) is overdiagnosed, but true incidence has increased as well. Owing to its excellent prognosis with low morbidity and mortality, balancing treatment risks with risks of disease progression can be challenging, leading to several areas of controversy. EVIDENCE ACQUISITION: This mini-review is an overview of controversies and difficult decisions around the management of all stages of low-risk DTC, from diagnosis through treatment and follow-up. In particular, overdiagnosis, active surveillance vs surgery, extent of surgery, radioactive iodine (RAI) treatment, thyrotropin suppression, and postoperative surveillance are discussed. EVIDENCE SYNTHESIS: Recommendations regarding the diagnosis of DTC, the extent of treatment for low-risk DTC patients, and the intensity of posttreatment follow-up have all changed substantially in the past decade. While overdiagnosis remains a problem, there has been a true increase in incidence as well. Treatment options range from active surveillance of small tumors to total thyroidectomy followed by RAI in select cases. Recommendations for long-term surveillance frequency and duration are similarly broad.
conclusionClinicians and patients must approach each case in a personalized and nuanced fashion to select the appropriate extent of treatment on an individual basis. In areas of evidential equipoise, data regarding patient-centered outcomes may help guide decision-making.
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