ReviewScience (New York, N.Y.)2022
Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI.
Review in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment.Journal of neurology, neurosurgery, and psychiatry · 2024Trial
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lifespan dynamics of STN-based functional connectivity and network properties: Implications for motor dysfunction and circuit-based neuromodulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Specific Neural Mechanisms Underlying Humans' Processing of Information Related to Companion Animals: A Comparison with Domestic Animals and Objects.Animals : an open access journal from MDPI · 2025Article
- Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage.Translational stroke research · 2025Article
- Estimating brain effective connectivity from time series using recurrent neural networks.Physical and engineering sciences in medicine · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Review
- Article
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- Sequential Deactivation Across the Hippocampus-Thalamus-mPFC Pathway During Loss of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- An EEG-based marker of functional connectivity: detection of major depressive disorder.Cognitive neurodynamics · 2024Article
- The mouse motor system contains multiple premotor areas and partially follows human organizational principles.Cell reports · 2024Article
- Towards full-stack deep learning-empowered data processing pipeline for synchrotron tomography experiments.Innovation (Cambridge (Mass.)) · 2024Review
- Cognitive mechanisms and neurological foundations of companion animals' role in enhancing human psychological well-being.Frontiers in psychology · 2024Review
- 3D-printed liquid metal polymer composites as NIR-responsive 4D printing soft robot.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Can we construct a model of brain function that enables an understanding of whole-brain circuit mechanisms underlying neurological disease and use it to predict the outcome of therapeutic interventions? How are pathologies in neurological disease, some of which are observed to have spatial spreading mechanisms, associated with circuits and brain function? In this review, we discuss approaches that have been used to date and future directions that can be explored to answer these questions. By combining optogenetic functional magnetic resonance imaging (fMRI) with computational modeling, cell type-specific, large-scale brain circuit function and dysfunction are beginning to be quantitatively parameterized. We envision that these developments will pave the path for future therapeutics developments based on a systems engineering approach aimed at directly restoring brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.