Evidence map›Paper›PMID 36327048›Full record

ArticleChinese journal of integrative medicine2023

Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.

Xiao-Fen Ge, Sha-Sha Li, Yan-Hua Liu, Mei-Qiu Lu, Hui-Na Su, Xin Yang, Xiao-Wan Sun

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Article in Chinese journal of integrative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiao-Fen GeDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Sha-Sha LiDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Yan-Hua LiuDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Mei-Qiu LuDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Hui-Na SuDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Xin YangDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China. xinyang_2003@sina.com.
Xiao-Wan SunDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, 100044, China.
Peking University People's Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the protective effect and mechanism of Kuntai (KT) Capsule on angiotensin II (Ang II)-induced hypertension in ovariectomized (OVX) rats.

methodsFifty-four rats were randomly divided into 6 groups according to a random number table, 9 in each group: control, OVX sham+Ang II, OVX, OVX+Ang II, OVX+Ang II +E

resultsCompared with the OVX+Ang II group, the systolic blood pressure of OVX+Ang II +KT group was significantly lowered (P<0.05) but not the diastolic blood pressure. Besides, SOD2 and TRX protein levels in mycardial tissues were significantly reduced in the OVX+Ang II +KT group compared with the OVX+Ang II group (P<0.05). Oxidative stress serum markers MDA and SOD were down- and up-regulated in the OVX+Ang II +KT group, respectively (P<0.05). Compared with OVX+Ang II group, the levels of cardiac proteins beclin-1 and LC3II/LC3 I in OVX+Ang II +KT group were also up-regulated (P<0.05), and the expression levels of p-PI3K, p-AKT and mTOR protein were down-regulated (P<0.05).

conclusionKT could protect blood pressure of Ang II-induced OVX rats by inhibiting oxidative stress and up-regulating protective autophagy.

Indexed as

Angiotensin IIHypertensionAnimalsDrugs, Chinese HerbalEstradiolFemaleHumansMammalsOvariectomyPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSuperoxide DismutaseAngiotensin IIDrugs, Chinese HerbalEstradiolkuntai capsulePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSuperoxide Dismutaseangiotensin IIChinese medicineKuntai Capsuleperimenopausal hypertension

Identifiers

PMID36327048
OpenAlexW4308052928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.