Evidence map›Paper›PMID 36326993›Full record

ReviewUnited European gastroenterology journal2022

Crohn's disease related strictures in cross-sectional imaging: More than meets the eye?

Joseph Sleiman, Prathyush Chirra, Namita S Gandhi, Mark E Baker, Cathy Lu, Ilyssa O Gordon, Satish E Viswanath, Florian Rieder, Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium

Abstract readReview
In one paragraph

Review in United European gastroenterology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. The Diagnosis of Intestinal Fibrosis in Crohn's Disease-Present and Future.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Imaging of Strictures in Crohn's Disease.Life (Basel, Switzerland) · 2023
    Review
  12. How to Evaluate Fibrosis in IBD?Diagnostics (Basel, Switzerland) · 2023
    Review
  13. Review
  14. Changing paradigms in management of inflammatory bowel disease.United European gastroenterology journal · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph SleimanDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7390-5949
Prathyush ChirraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Namita S GandhiImaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Mark E BakerImaging Institute, Digestive Diseases and Surgery Institute and Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Cathy LuDivision of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.
Ilyssa O GordonDepartment of Pathology, Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Satish E ViswanathDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Florian RiederDepartment of Gastroenterology, Hepatology & Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium

Funding

Creeping fat and Crohn's disease associated stricturesR01DK123233 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI RIEDER, FLORIAN · 2020 to 2024
$1.9M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
Radiomics-based Risk Prediction for Therapy Selection in Crohn’s Disease via MRIF31DK130587 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI CHIRRA, PRATHYUSH V · 2022 to 2022
$35k
NCI NIH HHS U01 CA248226NIDDK NIH HHS F31 DK130587NIDDK NIH HHS R01 DK123233
6 · The paper itself

Abstract

Strictures in Crohn's disease (CD) are a hallmark of long-standing intestinal damage, brought about by inflammatory and non-inflammatory pathways. Understanding the complex pathophysiology related to inflammatory infiltrates, extracellular matrix deposition, as well as muscular hyperplasia is crucial to produce high-quality scoring indices for assessing CD strictures. In addition, cross-sectional imaging modalities are the primary tool for diagnosis and follow-up of strictures, especially with the initiation of anti-fibrotic therapy clinical trials. This in turn requires such modalities to both diagnose strictures with high accuracy, as well as be able to delineate the impact of each histomorphologic component on the individual stricture. We discuss the current knowledge on cross-sectional imaging modalities used for stricturing CD, with an emphasis on histomorphologic correlates, novel imaging parameters which may improve segregation between inflammatory, muscular, and fibrotic stricture components, as well as a future outlook on the role of artificial intelligence in this field of gastroenterology.

Indexed as

Crohn DiseaseArtificial IntelligenceConstriction, PathologicFibrosisHumansIntestinescomputer tomography enterographyCrohn's diseasecross-sectional imagingfibrosisintestinal ultrasoundmagnetic resonance enterographyradiomicsstrictures

Identifiers

PMID36326993
PMCPMC9752301

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.