Evidence map›Paper›PMID 36326939›Full record

SynthesisTechniques in coloproctology2023

Impact of obesity on morbidity and oncologic outcomes after total mesorectal excision for mid and low rectal cancer.

L Gutierrez, A Bonne, B Trilling, A Foote, M-H Laverrière, G Roth, J Fournier, E Girard, J-L Faucheron

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Techniques in coloproctology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L GutierrezColorectal Unit, Department of Surgery, Grenoble Alpes University Hospital, 38000, Grenoble, France.
A BonneColorectal Unit, Department of Surgery, Grenoble Alpes University Hospital, 38000, Grenoble, France.
B TrillingColorectal Unit, Department of Surgery, Grenoble Alpes University Hospital, 38000, Grenoble, France.
A FooteResearch Division, Grenoble Alpes University Hospital, 38000, Grenoble, France.
M-H LaverrièreDepartment of Pathology, Grenoble Alpes University Hospital, 38000, Grenoble, France.
G RothDepartment of Hepato-Gastroenterology, Grenoble Alpes University Hospital, 38000, Grenoble, France.
J FournierDepartment of Public Health, Grenoble Alpes University Hospital, 38000, Grenoble, France.
E GirardColorectal Unit, Department of Surgery, Grenoble Alpes University Hospital, 38000, Grenoble, France.
J-L FaucheronColorectal Unit, Department of Surgery, Grenoble Alpes University Hospital, 38000, Grenoble, France. JLFaucheron@chu-grenoble.fr.ORCID 0000-0002-0837-2277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA recent meta-analysis showed that obesity increased the conversion rate and postoperative morbidity of rectal cancer surgery, but did not influence pathological results. However, this meta-analysis included patients with cancer of the upper rectum and had many biases. The aim of the present retrospective study was to investigate the impact of obesity, defined as a body mass index (BMI) ≥ 30 kg/m

methodsThis study included all eligible patients who were operated on for mid and lower rectal cancer between 1999 and 2018 in our hospital. We compared 90-day postoperative morbidity and mortality, and short- and long-term oncologic outcomes between obese and non-obese patients.

resultsThree hundred and ninety patients [280 males, mean age 65.7 ± 11.3 years, 59 obese individuals (15.1%)] were included. There was no difference in the 90-day mortality rate between obese and non-obese groups (p = 0.068). There was a difference in the overall 90-day morbidity rate between the obese and non-obese groups that disappeared after propensity score matching of the patients. There was no difference in short-term oncological parameters, with a median follow-up of 43 (20-84) months, and there were no significant differences in disease-free and overall survival between obese and non-obese patients (p = 0.42 and p = 0.11, respectively).

conclusionsObesity does not affect the 90-day morbidity rate, or short- and long-term oncologic results in patients operated on for mid and lower rectal cancer.

Indexed as

LaparoscopyRectal NeoplasmsAgedHumansMaleMiddle AgedObesityPostoperative ComplicationsRectumRetrospective StudiesTreatment OutcomeComplicationsLaparoscopyObesityOncological outcomesRectal cancerTotal mesorectal excision

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.