Evidence map›Paper›PMID 36326906›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.

Ann Helen Torstveit, Christine Miaskowski, Borghild Løyland, Ellen Karine Grov, Christine Seel Ritchie, Steven M Paul, Anna Marie Ellström Engh, Inger Utne

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ann Helen TorstveitDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Pilestredet 32, Oslo, Norway.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, CA, USA.
Borghild LøylandDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Pilestredet 32, Oslo, Norway.
Ellen Karine GrovDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Pilestredet 32, Oslo, Norway.
Christine Seel RitchieDivision of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Mongan Institute Center for Aging and Serious Illness, Boston, MA, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, CA, USA.
Anna Marie Ellström EnghDepartment of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway.
Inger UtneDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Pilestredet 32, Oslo, Norway. inger@oslomet.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStudy purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF.

methodsBalance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function associated with initial levels and changes over time in each of the tests were determined.

resultsGait speed and chair-stand tests improved over time. Balance declined until month 6, then increased. Characteristics associated with decreases in balance scores at initiation of chemotherapy were lower level of education and lower Karnofsky Performance Status (KPS) score. For initial levels of poorer gait speed, older age, poorer Trail Making Test B (TMTB), and worse Attentional Function Index scores were the associated characteristics. Lower KPS scores, higher body mass index, and poorer TMTB scores were associated with poorer chair-stand times at initiation of chemotherapy. Worse trajectories of chair-stand times were associated with poorer chair-stand time at enrollment. Characteristic associated with lower initial levels and improved trajectories of balance was older age at enrollment.

conclusionsDetermination of characteristics associated with decrements in balance, gait speed, and chair-stand can assist clinicians to identify older oncology patients at risk for decrements in PF. Interventions to maintain and improve PF need to be implemented with higher risk patients.

Indexed as

NeoplasmsAgedAttentionCognitionHumansBalanceCancerChemotherapyGait speedOlder patientsPhysical function

Identifiers

PMID36326906
PMCPMC9715479

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