ArticleEuropean journal of nutrition2023
Prenatal exposure to famine and the development of diabetes later in life: an age-period-cohort analysis of the China health and nutrition survey (CHNS) from 1997 to 2015.
Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 6 citations in OpenAlex.
- Association Between Salt Intake and Body Adiposity in Chinese Population: A Repeated-Measures Cohort Study.Nutrients · 2026Observational
- The association between early-life famine exposure and hypertension risk in adulthood and its interaction with dietary inflammatory index among Chinese adults.Frontiers in nutrition · 2026Article
- Association between serum platelet level and dermatitis rash: Results from the China Health and Nutrition Survey.PloS one · 2026Article
- Birth Weight, Cardiovascular Health, and Microvascular Complications in Individuals with Diabetes Mellitus.Diabetes & metabolism journal · 2025Article
- Mediterranean diet lowers risk of new-onset diabetes: a nationwide cohort study in China.Nutrition journal · 2024Article
- Early-life famine exposure and subsequent risk of chronic diseases in later adulthood: a population-based retrospective cohort study.Frontiers in public health · 2024Article
- Associations of micronutrients and lipids with prediabetes and glycemic parameters in adolescent girls of the rural DERVAN cohort (DERVAN-9).Frontiers in nutrition · 2024Article
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12 authors at 5 institutions in 3 countries.
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Abstract
purposePrenatal exposure to famine has been linked to increased diabetes risk in adulthood. However, one fundamental issue to be addressed is that the reported famine-diabetes relation may be confounded by the age differences between the exposed and non-exposed groups. We aimed to determine the association between prenatal exposure to the Chinese famine of 1959-1962 and risk of diabetes by applying age well-controlled strategies.
methodsAmong 20,535 individuals born in 1955-1966 who participated in the China Health and Nutrition Survey from 1997 to 2015, we constructed age-matched exposed vs. non-exposed groups to investigate the role of prenatal exposure to the Chinese famine of 1959-1962 in relation to diabetes. We also built a hierarchical age-period-cohort (HAPC) model to specifically examine the relation of famine to diabetes risk independent of age.
resultsCompared to the age-balanced men in the non-exposed group, the exposed men born in 1961 had a 154% increased risk of diabetes [odds ratio (OR) 2.54 (95% CI 1.07-6.03), P = 0.04). In the HAPC analysis, the predicted probabilities of diabetes peaked in the 1961-birth cohort of men [3.4% (95% CI 2.4%-5.0%)], as compared to the average probability of diabetes (reference) of 1.8% for men overall. Neither analytical strategy revealed any strong relation between famine exposure and diabetes risk in women.
conclusionAmong the pre-defined Chinese famine period of 1959-1962, early-life exposure to famine was associated with increased diabetes risk in men but not in women, and these relations were independent of age.
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