Evidence map›Paper›PMID 36326856›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2023

Automatic planning of the lower extremities for total marrow irradiation using volumetric modulated arc therapy.

Nicola Lambri, Damiano Dei, Victor Hernandez, Isabella Castiglioni, Elena Clerici, Leonardo Crespi, Chiara De Philippis, Daniele Loiacono, Pierina Navarria, Giacomo Reggiori and 5 more

Open access · hybridFull text read
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Nicola LambriDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy.ORCID 0000-0001-8706-6480
Damiano DeiDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy.ORCID 0000-0001-9873-7868
Victor HernandezDepartment of Medical Physics, Hospital Universitari Sant Joan de Reus, IISPV, Tarragona, Spain.ORCID 0000-0003-3770-8486
Isabella CastiglioniDepartment of Physics "G. Occhialini", University of Milan-Bicocca, piazza della Scienza 2, 20126, Milano, Italy.ORCID 0000-0001-7191-5417
Elena ClericiRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.ORCID 0000-0002-1765-863X
Leonardo CrespiDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.ORCID 0000-0001-6219-8444
Chiara De PhilippisBone Marrow Transplantation Unit, IRCCS Humanitas Research Hospital, Milan, Rozzano, Italy.ORCID 0000-0002-7738-997X
Daniele LoiaconoDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.ORCID 0000-0002-5355-0634
Pierina NavarriaRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.ORCID 0000-0002-6913-1442
Giacomo ReggioriDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy.ORCID 0000-0003-3336-5690
Roberto RusconiDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy.ORCID 0000-0002-8385-9296
Stefano TomatisRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.ORCID 0000-0002-4791-0373
Stefania BramantiBone Marrow Transplantation Unit, IRCCS Humanitas Research Hospital, Milan, Rozzano, Italy.ORCID 0000-0002-4117-7991
Marta ScorsettiDepartment of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy.ORCID 0000-0003-0320-559X
Pietro MancosuRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy. pietro.mancosu@humanitas.it.ORCID 0000-0002-0165-7931
IRCCS Humanitas Research Hospital · ITHumanitas University · ITHuman Technopole · ITInstitut de Recerca Biomèdica Catalunya Sud · ESPolitecnico di Milano · ITUniversity of Milano-Bicocca · IT

Funding

Ministero della Salute GR-2019-12370739
6 · The paper itself

Abstract

purposeTotal marrow (and lymphoid) irradiation (TMI-TMLI) is limited by the couch travel range of modern linacs, which forces the treatment delivery to be split into two plans with opposite orientations: a head-first supine upper-body plan, and a feet-first supine lower extremities plan. A specific field junction is thus needed to obtain adequate target coverage in the overlap region of the two plans. In this study, an automatic procedure was developed for field junction creation and lower extremities plan optimization.

methodsTen patients treated with TMI-TMLI at our institution were selected retrospectively. The planning of the lower extremities was performed automatically. Target volume parameters (CTV_J‑V

resultsThe automatic procedure required 60-90 min, depending on the case. All automatic plans achieved clinically acceptable dosimetric results (CTV_J‑V

conclusionThe developed procedure allowed treatment planning of TMI-TMLI to be streamlined, increasing efficiency and standardization, preventing human errors, while maintaining the dosimetric plan quality and complexity of manual plans. Automated strategies can simplify the future adoption and clinical implementation of TMI-TMLI treatments in new centers.

Indexed as

Bone MarrowRadiotherapy, Intensity-ModulatedHumansLower ExtremityOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesAutomationField junctionRadiotherapyTMIVMAT

Identifiers

PMID36326856
PMCPMC10033624
OpenAlexW4308053335

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read59
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.