Evidence map›Paper›PMID 36326795›Full record

ReviewReviews in the neurosciences2023

Simulation of oscillatory dynamics induced by an approximation of grid cell output.

Roger D Traub, Miles A Whittington, Mark O Cunningham

Open access · greenAbstract readReview
In one paragraph

Review in Reviews in the neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Roger D TraubAI Foundations, IBM T.J. Watson Research Center, Yorktown Heights, NY 10598, USA.
Miles A WhittingtonDepartment of Biology, Hull York Medical School, York YO10 5DD, UK.
Mark O CunninghamDiscipline of Physiology, School of Medicine, Trinity College Dublin, University of Dublin, 152-160 Pearse St., Dublin 2, Ireland.
Hull York Medical School · GBTrinity College Dublin · IEUniversity of Pennsylvania · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

Grid cells, in entorhinal cortex (EC) and related structures, signal animal location relative to hexagonal tilings of 2D space. A number of modeling papers have addressed the question of how grid firing behaviors emerge using (for example) ideas borrowed from dynamical systems (attractors) or from coupled oscillator theory. Here we use a different approach: instead of asking how grid behavior emerges, we take as a given the experimentally observed intracellular potentials of superficial medial EC neurons during grid firing. Employing a detailed neural circuit model modified from a lateral EC model, we then ask how the circuit responds when group of medial EC principal neurons exhibit such potentials, simultaneously with a simulated theta frequency input from the septal nuclei. The model predicts the emergence of robust theta-modulated gamma/beta oscillations, suggestive of oscillations observed in an

Indexed as

Grid CellsAction PotentialsAnimalsEntorhinal CortexGamma RhythmHumansNeuronsParvalbuminsParvalbuminsbeta/gamma oscillationscomputational modelkainate receptorsramp depolarizationspikeletstellate cells

Identifiers

PMID36326795
PMCPMC10329426
OpenAlexW4308060344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.