Evidence map›Paper›PMID 36326761›Full record

ArticleJAMA network open2022

Complexity and Challenges of the Clinical Diagnosis and Management of Long COVID.

Ann M O'Hare, Elizabeth K Vig, Theodore J Iwashyna, Alexandra Fox, Janelle S Taylor, Elizabeth M Viglianti, Catherine R Butler, Kelly C Vranas, Mark Helfand, Anaïs Tuepker and 11 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05394025 (COVID-19 Observational Research Collaboratory - Long-Term Outcomes), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05394025 completednot on this map

COVID-19 Observational Research Collaboratory - Long-Term Outcomes (LTO) Study

TypeobservationalSponsorVA Office of Research and DevelopmentRan2022 to 2024Enrolled479ConditionsCOVID-19, SARS-CoV-2 Infection
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Patient and Professional Perspectives on Long COVID: A Systematic Literature Review and Meta-Synthesis.International journal of environmental research and public health · 2025
    Pooled it
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  16. Involvement of oxidative stress in post-acute sequelae of COVID-19: clinical implications.Redox report : communications in free radical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 2 countries.

Ann M O'HareHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington.
Elizabeth K VigHospital and Specialty Medicine and Geriatrics and Extended Care Services, VA Puget Sound Health Care System, Seattle, Washington.
Theodore J IwashynaPulmonary and Critical Care Medicine, Department of Health Policy & Management, School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Alexandra FoxSeattle Epidemiologic Research and Information Center, VA Puget Sound, Seattle, Washington.
Janelle S TaylorDepartment of Anthropology, University of Toronto, Toronto, Canada.
Elizabeth M VigliantiDepartment of Internal Medicine Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor.
Catherine R ButlerHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington.
Kelly C VranasCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Mark HelfandCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Anaïs TuepkerCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Shannon M NugentCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Kara A WinchellCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Ryan J LaundryHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington.
C Barrett BowlingGeriatric Research Education and Clinical Center, Durham VA Medical Center, Durham, North Carolina.
Denise M HynesCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon.
Matthew L MaciejewskiCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
Amy S B BohnertVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Emily R LockeHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington.
Edward J BoykoHospital and Specialty Medicine and Geriatrics and Extended Care Services, VA Puget Sound Health Care System, Seattle, Washington.
George N IoannouHealth Services Research & Development Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington.
VA COVID Observational Research Collaboratory (CORC)
VA Puget Sound Health Care System · USVA Portland Health Care System · USOregon Health & Science University · USUniversity of Michigan–Ann Arbor · USUniversity of Puget Sound · USDuke University · USDurham VA Medical Center · USHealth Services Research & Development · USJohns Hopkins University · USOregon State University · USUniversity of Toronto · CA

Funding

Strengthening Shared Decision-Making for Older Adults with Kidney Failure Considering Kidney TransplantK23DK129777 · NIDDK · UNIVERSITY OF WASHINGTON · PI Catherine R Butler · 2022 to 2026
$930k
Optimizing Critical Care for Patients with Acute Respiratory Failure: A Mixed-Methods StudyIK2HX003005 · VA · PORTLAND VA MEDICAL CENTER · PI VRANAS, KELLY C. · 2020 to 2023
–
HSR&D Senior Research Career Scientist AwardIK6HX003395 · VA · PORTLAND VA MEDICAL CENTER · PI Denise M. Hynes · 2021 to 2026
–
HSRD VA IK2 HX003005HSRD VA IK6 HX003395NIDDK NIH HHS K23 DK129777
6 · The paper itself

Abstract

Importance: There is increasing recognition of the long-term health effects of SARS-CoV-2 infection (sometimes called long COVID). However, little is yet known about the clinical diagnosis and management of long COVID within health systems. Objective: To describe dominant themes pertaining to the clinical diagnosis and management of long COVID in the electronic health records (EHRs) of patients with a diagnostic code for this condition (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] code U09.9). Design, Setting, and Participants: This qualitative analysis used data from EHRs of a national random sample of 200 patients receiving care in the Department of Veterans Affairs (VA) with documentation of a positive result on a polymerase chain reaction (PCR) test for SARS-CoV-2 between February 27, 2020, and December 31, 2021, and an ICD-10 diagnostic code for long COVID between October 1, 2021, when the code was implemented, and March 1, 2022. Data were analyzed from February 5 to May 31, 2022. Main Outcomes and Measures: A text word search and qualitative analysis of patients' VA-wide EHRs was performed to identify dominant themes pertaining to the clinical diagnosis and management of long COVID. Results: In this qualitative analysis of documentation in the VA-wide EHR, the mean (SD) age of the 200 sampled patients at the time of their first positive PCR test result for SARS-CoV-2 in VA records was 60 (14.5) years. The sample included 173 (86.5%) men; 45 individuals (22.5%) were identified as Black and 136 individuals (68.0%) were identified as White. In qualitative analysis of documentation pertaining to long COVID in patients' EHRs 2 dominant themes were identified: (1) clinical uncertainty, in that it was often unclear whether particular symptoms could be attributed to long COVID, given the medical complexity and functional limitations of many patients and absence of specific markers for this condition, which could lead to ongoing monitoring, diagnostic testing, and specialist referral; and (2) care fragmentation, describing how post-COVID-19 care processes were often siloed from and poorly coordinated with other aspects of care and could be burdensome to patients. Conclusions and Relevance: This qualitative study of documentation in the VA EHR highlights the complexity of diagnosing long COVID in clinical settings and the challenges of caring for patients who have or are suspected of having this condition.

Indexed as

COVID-19Clinical Decision-MakingFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2Uncertainty

Identifiers

PMID36326761
PMCPMC9634500
OpenAlexW4308026479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.