Evidence map›Paper›PMID 36326370›Full record

ArticleTurkish journal of medical sciences2022

Evaluation of subclinical cardiovascular disease by carotid intima media thickness, epicardial adipose tissue thickness, serum endocan, and nesfatin-1 levels in patients with primary hyperparathyroidism.

Muhammet Kocabaş, Yakup Alsancak, Mustafa Can, İlker Çordan, Hatice Çalışkan Burgucu, Melia Karaköse, Fatma Hümeyra Yerlikaya, Mustafa Kulaksızoğlu, Feridun Karakurt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Muhammet KocabaşDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Yakup AlsancakDepartment of Cardiology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Mustafa CanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
İlker ÇordanDepartment of Endocrinology and Metabolism, Konya City Hospital, Konya, Turkey.
Hatice Çalışkan BurgucuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Melia KaraköseDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Fatma Hümeyra YerlikayaDepartment of Biochemistry, Faculty of Medicine, Selçuk University, Konya, Turkey.
Mustafa KulaksızoğluDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Feridun KarakurtDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Necmettin Erbakan University · TRKonya Eğitim ve Araştırma Hastanesi · TRSelçuk University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on the presence and extent of cardiovascular disease (CVD) risk in primary hyperparathyroidism (PHPT) are conflicting. In our study, we aimed to investigate the increased CVD risk in patients with PHPT by carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness, and serum levels of endocan and nesfatin-1.

methodsPatients with PHPT (n = 44) and age- and sex-matched healthy control subjects (n = 40) were enrolled in this study. Demographic data of the participants were questioned. Serum endocan and nesfatin-1 concentrations were assessed using commercially available ELISA kits. Noninvasive measurements of CIMT and EAT thickness were made with high-resolution ultrasonography and B-mode echocardiography.

resultsThere was no statistically significant difference in serum endocan and nesfatin-1 levels and EAT thickness in the PHPT group compared to controls. CIMT was statistically significantly higher in the PHPT group compared to controls (p = 0.001). A negative correlation was found between PTH and low-density lipoprotein cholesterol level (p = 0.001) but no significant relationship was found between other parameters. DISCUSSION: We found that CIMT is increased in patients with PHPT and consequently, CVD risk is high in these patients. More comprehensive studies are needed to identify other markers that predict increased CVD risk in patients with PHPT.

Indexed as

Cardiovascular DiseasesHyperparathyroidism, PrimaryAdipose TissueCarotid Intima-Media ThicknessHumansPericardiumRisk Factorscardiovascular disease riskcarotid intima media thicknessendocanepicardial adipose tissue thickness,nesfatin-1Primary hyperparathyroidism

Identifiers

PMID36326370
PMCPMC10387898
OpenAlexW4291779460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.