ArticleJournal of magnetic resonance imaging : JMRI2023
Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach.
Article in Journal of magnetic resonance imaging : JMRI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- A Multimodal MRI Study of the White Matter Microstructural and Hemodynamic Underpinnings of Cognitive Decline in Type 2 Diabetes Mellitus.Brain topography · 2026Article
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Age-related differences in choroid plexus structural integrity are associated with changes in cognition.Fluids and barriers of the CNS · 2025Article
- White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging.GeroScience · 2025Article
- Age-Related Differences in the Choroid Plexus Structural Integrity Are Associated with Changes in Cognition.medRxiv : the preprint server for health sciences · 2025Article
- Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan.Brain communications · 2024Article
- REUSED: A deep neural network method for rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled MRI.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2023Article
- The correlation between changes in gray matter microstructure and cerebral blood flow in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCerebral tissue integrity decline and cerebral blood flow (CBF) alteration are major aspects of motor and cognitive dysfunctions and neurodegeneration. However, little is known about the association between blood flow and brain microstructural integrity, especially in normal aging. PURPOSE: To assess the association between CBF and cerebral microstructural integrity. STUDY TYPE: Cross sectional. POPULATION: A total of 94 cognitively unimpaired adults (mean age 50.7 years, age range between 22 and 88 years, 56 Men). FIELD STRENGTH/SEQUENCE: A 3 T; pseudo-continuous arterial spin labeling (pCASL), diffusion tensor imaging (DTI), Bayesian Monte Carlo analysis of multicomponent driven equilibrium steady-state observation of T ASSESSMENT: Lobar associations between CBF derived from pCASL, and longitudinal relaxation rate (R STATISTICAL TESTS: Multiple linear regression models were used using the mean region of interest (ROI) values for MWF, R
resultsR DATA
conclusionThese findings suggest that cerebral tissue microstructure may be impacted by global brain perfusion, adding further evidence to the intimate relationship between cerebral blood supply and cerebral tissue integrity. EVIDENCE LEVEL: 4 TECHNICAL EFFICACY: Stage 4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.