Evidence map›Paper›PMID 36326091›Full record

ArticleeLife2022

A conserved function of Human DLC3 and

Sol Sotillos, Isabel von der Decken, Ivan Domenech Mercadé, Sriraksha Srinivasan, Dmytro Sirokha, Ludmila Livshits, Stefano Vanni, Serge Nef, Anna Biason-Lauber, Daniel Rodríguez Gutiérrez and 1 more

Abstract read
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In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sol SotillosCentro Andaluz de Biología del Desarrollo, Seville, Spain.ORCID 0000-0003-4731-8107
Isabel von der Decken *Department of Endocrinology, Metabolism and Cardiovascular research, University of Fribourg, Fribourg, Switzerland.
Ivan Domenech Mercadé *Department of Endocrinology, Metabolism and Cardiovascular research, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0003-2115-8475
Sriraksha SrinivasanDepartment of Biology, University of Fribourg, Fribourg, Switzerland.
Dmytro SirokhaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Ludmila LivshitsInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Stefano VanniDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0003-2146-1140
Serge NefDepartment of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-5462-0676
Anna Biason-LauberDepartment of Endocrinology, Metabolism and Cardiovascular research, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0001-8966-2913
Daniel Rodríguez Gutiérrez *Department of Endocrinology, Metabolism and Cardiovascular research, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-2979-0769
James Castelli-Gair Hombría *Centro Andaluz de Biología del Desarrollo, Seville, Spain.ORCID 0000-0003-4183-5250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification of genes affecting gonad development is essential to understand the mechanisms causing Variations/Differences in Sex Development (DSD). Recently, a DLC3 mutation was associated with male gonadal dysgenesis in 46,XY DSD patients. We have studied the requirement of Cv-c, the

Indexed as

Drosophila ProteinsGonadal DysgenesisAnimalsDrosophilaGerm CellsGTPase-Activating ProteinsHumansMaleSex DifferentiationTestiscv-c protein, DrosophilaDrosophila ProteinsGTPase-Activating ProteinsSTARD8 protein, human46,XY gonadal dysgenesisdeleted in liver cancer/Cv-cdevelopmental biologyD. melanogasterDrosophila testishumanhuman gonadogenesisStART-RhoGAP domain

Identifiers

PMID36326091
PMCPMC9678365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.