Evidence map›Paper›PMID 36325810›Full record

ArticleChemMedChem2023

Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease.

Niklas J Braun, Simon Huber, Luna C Schmacke, Andreas Heine, Torsten Steinmetzer

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Niklas J BraunInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032, Marburg, Germany.ORCID 0000-0002-2701-669X
Simon HuberInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032, Marburg, Germany.ORCID 0000-0002-8067-0447
Luna C SchmackeInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032, Marburg, Germany.ORCID 0000-0003-1229-4248
Andreas HeineInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032, Marburg, Germany.ORCID 0000-0002-5285-4089
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032, Marburg, Germany.ORCID 0000-0001-6523-4754
Philipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Zika virus (ZIKV) remains a potential threat to the public health due to the lack of both an approved vaccination or a specific treatment. In this work, a series of peptidic inhibitors of the ZIKV protease with boroleucine as P1 residue was synthesized. The highest affinities with K

Indexed as

Antiviral AgentsProtease InhibitorsZika VirusZika Virus InfectionBoron CompoundsHumansLeucinePeptide HydrolasesProtein BindingSerine EndopeptidasesViral Nonstructural ProteinsAntiviral AgentsboroleucineBoron CompoundsLeucinePeptide HydrolasesProtease InhibitorsSerine EndopeptidasesViral Nonstructural Proteinsboroleucinecrystal structure determinationdrug designNS2B-NS3 proteaseZika virus

Identifiers

PMID36325810
PMCPMC10100045
OpenAlexW4308059317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.