Evidence map›Paper›PMID 36325603›Full record

ArticleJournal of extracellular vesicles2022

Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells.

Zuzana Ditte, Ivan Silbern, Peter Ditte, Henning Urlaub, Gregor Eichele

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Apocrine secretion by the choroid plexus.Fluids and barriers of the CNS · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zuzana DitteDepartment of Genes and Behavior, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Ivan SilbernThe Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Peter DitteDepartment of Genes and Behavior, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Henning UrlaubThe Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Gregor EicheleDepartment of Genes and Behavior, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The choroid plexus secrets cerebrospinal fluid (CSF) composed of electrolytes, cytokines, growth factors, metabolites and extracellular vesicles (EVs) that flow through the interconnected brain ventricles. On their course, CSF components can act as signals that affect, for example, neural stem cells (NSCs) residing in niches of the ventricular wall. We studied EV-born CSF signals in an in vitro culture system. We purified EVs from the secretome of a choroid plexus cell line (Z310 cells), and from primary choroid plexus cultures and co-cultured those EVs with NSCs isolated from the niche of the lateral and the third ventricle. EVs

Indexed as

Extracellular VesiclesNeural Stem CellsCell DifferentiationChoroid PlexusCoculture Techniquesbrain ventriclescerebrospinal fluidchoroid plexus derived vesicleexosome assayextracellular vesiclesmass spectrometryneural stem cell differentiation

Identifiers

PMID36325603
PMCPMC9630752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.