ArticleFrontiers in psychiatry2022
Gray matter, white matter and cerebrospinal fluid abnormalities in Parkinson's disease: A voxel-based morphometry study.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Loss of Neocortical Oligodendrocytes in Parkinson's Disease Patients-A Stereological Study.Journal of neuroscience research · 2026Article
- Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation.Nature communications · 2026Article
- Brain-Inspired Multisensory Learning: A Systematic Review of Neuroplasticity and Cognitive Outcomes in Adult Multicultural and Second Language Acquisition.Biomimetics (Basel, Switzerland) · 2025Review
- From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care.Biomedicines · 2025Review
- Dopamine-mediated improvements of the step threshold task in Parkinson's disease: validation against clinical measures of motor and cognitive function.Frontiers in human neuroscience · 2025Article
- Parkinson's disease in the spinal cord: An exploratory study to establish T2*w, MTR and diffusion-weighted imaging metric values.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- AI-assisted MRI segmentation analysis of brain region volume alterations in Parkinson's disease.Frontiers in human neuroscience · 2025Article
- Resting-state functional connectivity of the occipital cortex in different subtypes of Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain.International journal of molecular sciences · 2024Article
- Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry.Biomedicines · 2024Article
- Voxel-based morphometry of grey matter structures in Parkinson's Disease with wearing-off.Brain imaging and behavior · 2023Article
- Article
- From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment.Cells · 2023Review
- White matter changes in Parkinson's disease.NPJ Parkinson's disease · 2023Review
- The effects of AQP4 rs162009 on resting-state brain activity in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis.Biomedicines · 2023Article
- Early-onset Alzheimer's disease with depression as the first symptom: a case report with literature review.Frontiers in psychiatry · 2023Article
- Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques.Frontiers in psychiatry · 2023Article
- Abnormal whole-brain voxelwise structure-function coupling and its association with cognitive dysfunction in patients with different cerebral small vessel disease burdens.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by bradykinesia, tremor, and rigidity among other symptoms. With a 70% cumulative prevalence of dementia in PD, cognitive impairment and neuropsychiatric symptoms are frequent. Materials and methods: In this study, we looked at anatomical brain differences between groups of patients and controls. A total of 138 people with PD were compared to 64 age-matched healthy people using voxel-based morphometry (VBM). VBM is a fully automated technique that allows for the identification of regional differences in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) allowing for an objective comparison of brains of different groups of people. We used statistical parametric mapping for image processing and statistical analysis. Results: In comparison to controls, PD patients had lower GM volumes in the left middle cingulate, left lingual gyrus, right calcarine and left fusiform gyrus, also PD patients indicated lower WM volumes in the right middle cingulate, left lingual gyrus, right calcarine, and left inferior occipital gyrus. Moreover, PD patients group demonstrated higher CSF in the left caudate compared to the controls. Conclusion: Physical fragility and cognitive impairments in PD may be detected more easily if anatomical abnormalities to the cingulate gyrus, occipital lobe and the level of CSF in the caudate are identified. Thus, our findings shed light on the role of the brain in PD and may aid in a better understanding of the events that occur in PD patients.
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