SynthesisFrontiers in immunology2022
Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis.
Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive Value of Red Blood Cell Distribution Width for the Prognosis of Cardiac Arrest: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2024Pooled it
- An interpretable machine learning model for early prediction of subsequent observed CRRT initiation in patients with sepsis-associated acute kidney injury.Clinical and experimental medicine · 2026Observational
- [Elevation of red blood cell distribution width to hematocrit ratio is associated with increased 28-day all-cause mortality in septic patients].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Machine learning-based precision subtyping and risk prediction in sepsis: a retrospective analysis using MIMIC-IV database.BMC infectious diseases · 2026Article
- Relationship between red cell distribution width to albumin ratio (RAR) and mortality in ICU patients with sepsis-associated ARDS: a retrospective study based on MIMIC-IV.BMC infectious diseases · 2026Article
- Characterizing bacteremia in neonatal calves with diarrhea: a case-control study.Journal of veterinary internal medicine · 2026Article
- Prognostic utility of red blood cell distribution width-based ratios and their individual components for mortality prediction in dogs with acute pancreatitis.Frontiers in veterinary science · 2026Article
- Machine learning model for predicting the risk of AKI in early hemodynamically stable sepsis patients: a study based on the MIMIC IV database.Frontiers in medicine · 2026Article
- Predicting sepsis prognosis using deep learning with routine biomarkers.Frontiers in medicine · 2026Article
- Article
- Risk Factors for Sepsis in Pediatric All During Induction Chemotherapy-Induced Neutropenia: A Single-Center Retrospective Study.Infection and drug resistance · 2026Article
- Association between hemoglobin/red blood cell distribution width ratio and acute kidney injury in sepsis and heart failure patients.PloS one · 2026Article
- Article
- Impact of the red blood cell distribution width-to-albumin ratio on neurological outcomes in cardiac arrest patients.Frontiers in neurology · 2026Observational
- A Machine Learning-Based Prognostic Model for Sepsis-Associated Liver Injury Using Routine Indicators.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Red Cell Distribution Width (RDW), Platelets and Platelet Index MPV/PLT Ratio as Specific Time Point Predictive Variables of Survival Outcomes in COVID-19 Hospitalized Patients.Journal of clinical medicine · 2025Article
- Association of overactive bladder with red cell distribution width to albumin ratio in American.Scientific reports · 2025Article
- Red cell distribution width and clinical outcomes in sepsis patients infected with Escherichia coli using data from MIMIC-IV.European journal of medical research · 2025Article
- The association between week-one red blood cell distribution width and one-year survival in critically ill patients: propensity score-based multicenter analysis.European journal of medical research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Red blood cell distribution width (RDW) is a common biomarker of bacterial infections, and it can be easily obtained from a routine blood test. We investigate the diagnostic value of RDW for the prediction of mortality in adult sepsis patients through a review and meta-analysis. We registered this review in PROSPERO (Registration Number: CRD42022357712), and the details of the registration are included in Appendix 1. Methods: We searched PubMed, Cochrane Library, Springer, and Embase between Jan. 1, 2000, and May 30, 2022, for primary studies about this research. We collected articles that investigated RDW for varying degrees of sepsis patients-those who suffered from sepsis, severe sepsis, or sepsis shock. Studies of healthy people and sepsis of children and neonates were excluded from our research. The definition of study characteristics and data extraction were finished by two independent researchers and discrepancies resolved by consensus. The combined sensitivities and specificities were calculated by meta-analysis using STATA14.0. The sensitivity of the included studies was analyzed by excluding studies that had potential heterogeneity. A summary operating characteristic curve was made to evaluate the diagnostic value for the prediction of mortality in adult sepsis patients. The Fagan test was used to explore likelihood ratios and posttest probabilities. Finally, we investigated the source of heterogeneity using meta-regression. Results: Twenty-four studies, including 40,763 cases altogether, were included in this analysis. Bivariate analysis indicated a combined sensitivity of 0.81 (95% CI 0.73-0.86) and specificity of 0.65 (95% CI 0.54-0.75). The area under the summary receiver operating characteristic curve was 0.81 (95% CI 0.77-0.84). Substantial heterogeneity resided in the studies ( Conclusions: RWD is an available and valuable biomarker for prediction of mortality in adult sepsis patients. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022357712.
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