ArticleBiological psychiatry global open science2021
I Doubt It Is Safe: A Meta-analysis of Self-reported Intolerance of Uncertainty and Threat Extinction Training.
Article in Biological psychiatry global open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Context-specific allocation of attentional control in anxiety and uncontrollability.Cognitive processing · 2026Article
- Exploring the role of interoception in anxious traits and symptoms.Frontiers in psychiatry · 2026Article
- Threat expectancies in a VR fear conditioning paradigm follow non-linear extinction patterns but are not influenced by intolerance of uncertainty.Scientific reports · 2025Article
- Intra-individual comparison of appetitive trace and delay conditioning in humans across acquisition and extinction.Scientific reports · 2025Article
- Extinction and beyond: an expanded framework for exposure and response prevention for obsessive-compulsive disorder.Frontiers in psychology · 2024Article
- Intolerance of Uncertainty as a Cognitive Vulnerability for Obsessive-Compulsive Disorder: A Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2023Article
- Intolerance of uncertainty heightens negative emotional states and dampens positive emotional states.Frontiers in psychiatry · 2023Article
- Fear-potentiated startle reveals diminished threat extinction in pathological anxiety.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Intolerance of uncertainty, anxiety sensitivity, and health anxiety during the COVID-19 pandemic: Exploring temporal relationships using cross-lag analysis.Journal of anxiety disorders · 2023Article
- Understanding clinical fear and anxiety through the lens of human fear conditioning.Nature reviews psychology · 2023Review
- Model-based prioritization for acquiring protection.PLoS computational biology · 2022Article
- The Relationship between Intolerance of Uncertainty and Problematic Social Media Use during the COVID-19 Pandemic: A Serial Mediation Model.International journal of environmental research and public health · 2022Article
- Using what we know about threat reactivity models to understand mental health during the COVID-19 pandemic.Behaviour research and therapy · 2022Article
- COVID-19 information overload: Intolerance of uncertainty moderates the relationship between frequency of internet searching and fear of COVID-19.Acta psychologica · 2022Article
- The Prevalence of Fear of Childbirth and Its Association With Intolerance of Uncertainty and Coping Styles Among Pregnant Chinese Women During the COVID-19 Pandemic.Frontiers in psychiatry · 2022Article
- When Uncertainty Is a Certainty: Optimizing Exposure-Based Therapies.Biological psychiatry global open science · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intolerance of uncertainty (IU), the tendency to find uncertainty distressing, is an important transdiagnostic dimension in mental health disorders. Higher self-reported IU has been linked to poorer threat extinction training (i.e., the updating of threat to safe associations), a key process that is targeted in exposure-based therapies. However, it remains to be seen whether IU-related effects during threat extinction training are reliably and specifically driven by the IU construct or a particular subcomponent of the IU construct over other self-reported measures of anxiety. Methods: A meta-analysis of studies from different laboratories (18 experiments; sample Results: All the self-reported variants of IU, but not trait anxiety, were associated with threat extinction training via skin conductance response (i.e., continued responding to the old threat cue). Specificity was observed for the majority of self-reported variants of IU over trait anxiety. Conclusions: The findings suggest that the IU construct broadly accounts for difficulties in threat extinction training and is specific over other measures of self-reported anxiety. These findings demonstrate the robustness and specificity of IU-related effects during threat extinction training and highlight potential opportunities for translational work to target uncertainty in therapies that rely on threat extinction principles such as exposure therapy.
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