Evidence map›Paper›PMID 36325298›Full record

ArticleBiological psychiatry global open science2021

Unique Morphometric Features of the Cerebellum and Cerebellocerebral Structural Correlation Between Autism Spectrum Disorder and Schizophrenia.

Chie Morimoto, Yuko Nakamura, Hitoshi Kuwabara, Osamu Abe, Kiyoto Kasai, Hidenori Yamasue, Shinsuke Koike

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chie MorimotoDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yuko NakamuraUTokyo Center for Integrative Science of Human Behaviour, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan.
Hitoshi KuwabaraDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hidenori YamasueDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, Japan.
Shinsuke KoikeUTokyo Center for Integrative Science of Human Behaviour, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although cerebellar morphological involvement has been increasingly recognized in autism spectrum disorder (ASD) and schizophrenia (SZ), the extent to which there are morphological differences between them has not been definitively quantified. Furthermore, although previous studies have demonstrated increased anatomical cerebellocerebral correlations in both conditions, differences between their associations have not been well characterized. Methods: We compared cerebellar volume between males with ASD ( Results: We found significantly larger WM volume in the bilateral lobules VI and Crus I in the ASD group than in other groups. While WM or GM volumes of these right lobules had positive associations with ASD symptoms, there was a negative association between GM volume of the right Crus I and SZ symptoms. We further observed, in the ASD group specifically, significant correlations between WM of the right lobule VI and WM of the left frontal pole ( Conclusions: Our findings support evidence that cerebellar morphology is involved in ASD and SZ with different mechanisms. Furthermore, this study showed that these biological differences require consideration when determining diagnostic criteria and treatment for these disorders.

Indexed as

Autism spectrum disorderCerebellocerebral structureCerebellumMRISchizophreniaStructural neuroimage

Identifiers

PMID36325298
PMCPMC9616290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.