Evidence map›Paper›PMID 36325297›Full record

ArticleMolecular and clinical oncology2022

Dendritic cells transfected with a polyepitope DNA construct stimulate an antitumor cytotoxic response in various tumors.

Vasily Kurilin, Ekaterina Kulikova, Julia Shevchenko, Julia Lopatnikova, Irina Obleukhova, Julia Khantakova, Amir Maksyutov, Maria Kuznetsova, Alexander Khristin, Natalya Kiryshina and 6 more

Abstract read
In one paragraph

Article in Molecular and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Vasily KurilinFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Ekaterina KulikovaFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Julia ShevchenkoFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Julia LopatnikovaFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Irina ObleukhovaFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Julia KhantakovaFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Amir MaksyutovFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Maria KuznetsovaFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Alexander KhristinState Clinical Hospital No. 1, Novosibirsk, Novosibirsk 630075, Russian Federation.
Natalya KiryshinaNovosibirsk Regional Clinical Oncological Center, Novosibirsk, Novosibirsk 630108, Russian Federation.
Vadim KozlovNovosibirsk Regional Clinical Oncological Center, Novosibirsk, Novosibirsk 630108, Russian Federation.
Sergey SidorovState Clinical Hospital No. 1, Novosibirsk, Novosibirsk 630075, Russian Federation.
Andrey SokolovState Clinical Hospital No. 1, Novosibirsk, Novosibirsk 630075, Russian Federation.
Alexander VitsinState Clinical Hospital No. 1, Novosibirsk, Novosibirsk 630075, Russian Federation.
Hiroshi ShikuFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.
Sergey SennikovFederal State Budgetary Scientific Institution 'Research Institute of Fundamental and Clinical Immunology', Novosibirsk 630099, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) are known to be crucial for the antitumor response and are still included in various treatment regimens in cancer immunotherapy research. In the present study, a cell-based protocol was evaluated, involving the use of original DNA constructs encoding the wide range of TAA epitopes expressed on different epithelial cancers. The constructs were transfected into

Indexed as

cytotoxicitydendritic cellsepithelial cancerpolyepitope DNA constructT-cells

Identifiers

PMID36325297
PMCPMC9618840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.