Evidence map›Paper›PMID 36325272›Full record

ArticleExpert review of ophthalmology2021

Spotlight on ocular Kaposi's sarcoma: an update on the presentation, diagnosis, and management options.

Nandini Venkateswaran, Juan C Ramos, Adam K Cohen, Osmel P Alvarez, Noah K Cohen, Anat Galor, Carol L Karp

Abstract read
In one paragraph

Article in Expert review of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. The critical role of primary care clinicians in the early detection of ocular surface squamous neoplasia.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
    Article
  7. Article
  8. Infectious etiologies of conjunctival tumors.Expert review of ophthalmology · 2025
    Article
  9. Article
  10. Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nandini VenkateswaranMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Juan C RamosSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Adam K CohenBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Osmel P AlvarezBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Noah K CohenBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Anat GalorBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Carol L KarpBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
BLRD VA I01 BX004893CSRD VA I01 CX002015NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174NEI NIH HHS R61 EY032468
6 · The paper itself

Abstract

Introduction: Kaposi's sarcoma (KS) is a multifocal low-grade vascular neoplasm that can affect the skin, mucus membranes, visceral organs, and lymph nodes. KS can also affect the ocular surface and adnexa and can masquerade as other entities, delaying prompt diagnosis. Areas covered: In this review, the manifestations of ocular KS are discussed along with theories for pathogenesis, common risk factors, and management options. Expert opinion: KS is caused by the oncogenic human herpesvirus 8 (HHV8). Immunosuppression in patients with HIV and AIDS contributes to the development of KS but conjunctival and ocular adnexal KS lesions are now uncommon in the era of anti-retroviral therapy. A high index of suspicion is required to diagnose ocular KS as these lesions can be mistaken for alternative entities. Prompt diagnosis can reduce significant morbidity and mortality by prompting a multidisciplinary systemic evaluation, particularly in immunosuppressed individuals. While surgical excision, cryotherapy, intralesional or systemic chemotherapy, and radiation are all viable treatment options, ongoing research to identify novel therapies and molecular treatment targets will help expand the armamentarium of therapeutics available for this disease.

Indexed as

acquired immunodeficiency syndromeconjunctival Kaposi’s sarcomahuman herpesvirus 8human immunodeficiency virusKaposi’s sarcomaocular adnexal Kaposi’s sarcomaopportunistic diseases

Identifiers

PMID36325272
PMCPMC9624465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.