ArticleBiological psychiatry global open science2022
Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study.
Article in Biological psychiatry global open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- Menarche onset is an inflection point for mental health and brain development.bioRxiv : the preprint server for biology · 2026Article
- Household Adversity, Day to Day Experiences, and Birth/Pregnancy Complications are Associated with Delay Discounting: Findings from the Adolescent Brain Cognitive Development Study.Research on child and adolescent psychopathology · 2026Article
- Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences.Nature. Mental health · 2026Article
- Combining the Risk: The Poly-Environmental Risk Score and Psychotic Symptoms in Adolescents.Schizophrenia bulletin · 2025Article
- Environmental Adversity Is Associated With Attenuated Positive Symptoms and Complex Cognition in a Long-term Follow-up of the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants.Psychological medicine · 2025Article
- Integration of positive environmental factors and differentiation of parental figures in social exposome research.Frontiers in psychology · 2025Article
- Environmental Toxicant Exposure and Depressive Symptoms.JAMA network open · 2024Article
- A general exposome factor explains individual differences in functional brain network topography and cognition in youth.Developmental cognitive neuroscience · 2024Article
- Probing the digital exposome: associations of social media use patterns with youth mental health.NPP - digital psychiatry and neuroscience · 2024Article
- Multilayer network associations between the exposome and childhood brain development.bioRxiv : the preprint server for biology · 2023Article
- Cumulative Environmental Risk in Early Life: Associations With Schizotypy in Childhood.Schizophrenia bulletin · 2023Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Restoring the missing person to personalized medicine and precision psychiatry.Frontiers in neuroscience · 2023Article
- Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis.Biological psychiatry global open science · 2022Review
- Introduction to the Special Issue on the Exposome-Understanding Environmental Impacts on Brain Development and Risk for Psychopathology.Biological psychiatry global open science · 2022Article
- Modeling environment through a general exposome factor in two independent adolescent cohorts.Exposome · 2022Article
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6 authors.
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Abstract
Background: The exposome comprises all nongenetic factors an individual is exposed to across their lifespan. Research suggests that exposomic vulnerability for schizophrenia is associated not only with psychosis but also, to a degree, with general psychopathology. Here, we investigated to what degree exposome factors are associated with psychosis and general psychopathology. Methods: Data were retrieved from the 1-year follow-up assessment of a large U.S. adolescent sample ( Results: Individual analyses showed that 5 exposome factors were significantly associated with the p-factor after multiple-comparison correction. In the mutually adjusted model, all exposome factors were significantly associated with the p-factor. Psychosis was particularly associated with 3 exposome factors, with the mutually adjusted model yielding the following results: household adversity (β = 0.04, 95% CI, 0.01 to 0.07), day-to-day experiences (β = 0.10, 95% CI, 0.08 to 0.12), and pregnancy/birth complications (β = 0.03, 95% CI, 0.01 to 0.05). Conclusions: Our findings demonstrate that multifaceted environmental background is associated with mental disorders. Psychosis was particularly associated with prenatal, perinatal, and childhood (household and school) adversities, although these exposome domains were also associated with psychopathology. The exposome approach can help understand neurodevelopmental psychopathology.
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