ReviewBiological psychiatry global open science2022
Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis.
Review in Biological psychiatry global open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- Menarche onset is an inflection point for mental health and brain development.bioRxiv : the preprint server for biology · 2026Article
- Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Time to incorporate positive experiences and outcomes in psychosis research: genetic differential susceptibility to childhood experiences works for "better and for worse".Translational psychiatry · 2025Article
- Development and Validation of a Brief Age-Normed Screening Tool for Subthreshold Psychosis Symptoms in Youth.Schizophrenia bulletin · 2025Article
- What are set and setting: Reducing vagueness to improve research and clinical practice.Journal of psychopharmacology (Oxford, England) · 2025Article
- Association Between Extreme Heat and Externalizing Symptoms in Pre- and Early Adolescence: Findings From the ABCD Study.JAACAP open · 2025Article
- The Ethics of Set and Setting in Psychedelic Psychotherapy.Neuroethics · 2025Article
- Precision psychiatry roadmap: towards a biology-informed framework for mental disorders.Molecular psychiatry · 2025Review
- The Philadelphia Neurodevelopmental Cohort: Perspective, Lessons, and Future Directions.Schizophrenia bulletin · 2025Article
- Environmental Adversity Is Associated With Attenuated Positive Symptoms and Complex Cognition in a Long-term Follow-up of the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- A roadmap for better and personalized mental health care in Europe - the action plan of the European Psychiatric Association.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Integration of positive environmental factors and differentiation of parental figures in social exposome research.Frontiers in psychology · 2025Article
- Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts.JAMA psychiatry · 2024Article
- Childhood Adversity Determines the Syndemic Effects of Violence, Substance Misuse, and Sexual Behavior on Psychotic Spectrum Disorder Among Men.Schizophrenia bulletin · 2024Article
- A general exposome factor explains individual differences in functional brain network topography and cognition in youth.Developmental cognitive neuroscience · 2024Article
- The Role of Individual Discrimination and Structural Stigma in the Mental Health of Sexual Minority Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence.Current neuropharmacology · 2024Review
- Probing the digital exposome: associations of social media use patterns with youth mental health.NPP - digital psychiatry and neuroscience · 2024Article
- The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health.The Journal of pediatrics · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The prenatal period, early childhood, and adolescence are considered sensitive periods for brain and behavior development, when environmental exposures may have long-lasting effects on mental health. Psychosis spectrum disorder (PSD) is a developmental disorder that often manifests with nonspecific clinical presentations long before full-blown PSD is diagnosed. Genetic factors only partly explain PSD. Multiple early-life environmental exposures are associated with PSD. In this review, we describe the conceptual framework of the exposome and its relevance to PSD research in developmental cohorts and beyond and discuss key challenges for the field as it attempts to move beyond studying environment (in the sense of "searching under the lamppost because this is where the light is") to a more comprehensive assessment of environment and its contribution to PSD. We then suggest that the field should aspire to studying environmental origins of PSD through a developmental lens focusing on young cohorts and using multilevel phenotyping of environment, adopting an exposome framework that embraces the dynamic complex nature of environment and acknowledges the effect of additive and interactive environmental exposures alongside the genome. Furthermore, we highlight the need for a developmental perspective when studying exposome effects on psychopathology, accepting the nonspecificity of child/adolescent psychopathology and encouraging the study of trans-syndromal manifestations, shifting the research paradigm from categorical outcomes (e.g., schizophrenia) and going beyond clinical settings to investigate trajectories of risk and resilience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.