Evidence map›Paper›PMID 36325020›Full record

ArticleFrontiers in microbiology2022

A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome.

Nyaradzo T L Chigorimbo-Murefu, Matthys Potgieter, Sonwabile Dzanibe, Zikhona Gabazana, Gershom Buri, Aditya Chawla, Bokani Nleya, Abraham J Olivier, Rushil Harryparsad, Bridget Calder and 10 more

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In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nyaradzo T L Chigorimbo-MurefuDivisions of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Matthys PotgieterDivision of Computational Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Sonwabile DzanibeDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Zikhona GabazanaDivision of Computational Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Gershom BuriDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Aditya ChawlaDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Bokani NleyaDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Abraham J OlivierDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Rushil HarryparsadDivisions of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Bridget CalderDivision of Chemical and Systems Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Shaun GarnettDivision of Chemical and Systems Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Lungile MaziyaDepartment of Medicine, Edendale Hospital, Pietermaritzburg, South Africa.
David A LewisWestern Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, NSW, Australia.
Heather JaspanDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Doug WilsonDepartment of Medicine, Edendale Hospital, Pietermaritzburg, South Africa.
Jo-Ann S PassmoreDivisions of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Nicola MulderDivision of Computational Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Jonathan BlackburnDivision of Chemical and Systems Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Centre, Cape Town, South Africa.
Clive M GrayDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Funding

Barrier integrity, microbiome and HIV target cell interactions in the human male genital tract pre and post circumcisionR01DK108434 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOPE, THOMAS · 2017 to 2022
$3.1M
NIDDK NIH HHS R01 DK108434
6 · The paper itself

Abstract

There is limited data on the role of asymptomatic STIs (aSTIs) on the risk of human immunodeficiency virus (HIV) acquisition in the male genital tract (MGT). The impact of foreskin removal on lowering HIV acquisition is well described, but molecular events leading to HIV acquisition are unclear. Here, in this pilot study, we show that asymptomatic urethral infection with

Indexed as

asymptomatic sexually transmitted infectionforeskinforeskin proteomegene ontology enrichment analysisHIV susceptibility

Identifiers

PMID36325020
PMCPMC9618803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.