Evidence map›Paper›PMID 36325010›Full record

ArticleClinical kidney journal2022

Healthcare resource utilisation and related costs of patients with CKD from the UK: a report from the DISCOVER CKD retrospective cohort.

Carol Pollock, Glen James, Juan Jose Garcia Sanchez, Juan Jesus Carrero, Matthew Arnold, Carolyn S P Lam, Hungta Tony Chen, Stephen Nolan, Roberto Pecoits-Filho, David C Wheeler

Abstract read
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Effect of semaglutide on COVID-19 and other infections: an analysis from the FLOW randomized clinical trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Trial
  2. Article
  3. Article
  4. Article
  5. International Environmental Impact of CKD Care.Kidney international reports · 2026
    Article
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  8. Review
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  12. Review
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carol PollockKolling Institute, Royal North Shore Hospital University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-7167-6495
Glen JamesBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Juan Jose Garcia SanchezBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Juan Jesus CarreroKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-4763-2024
Matthew ArnoldBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Carolyn S P LamNational Heart Centre, Department of Cardiology, Singapore, Singapore.ORCID https://orcid.org/0000-0003-1903-0018
Hungta Tony ChenAstraZeneca, Gaithersburg, MD, USA.
Stephen NolanBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Roberto Pecoits-FilhoSchool of Medicine, Pontifical Catholic University of Parana, Curitiba, Brazil.
David C WheelerDepartment of renal medicine, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD) is widely reported to decrease quality of life, increase morbidity and mortality and cause increased healthcare resource utilisation (HCRU) as the disease progresses. However, there is a relative paucity of accurate and recent estimates of HCRU in this patient population. Our aim was to address this evidence gap by reporting HCRU and related costs in patients with CKD from the UK primary and secondary care settings. Methods: HCRU and cost estimates of CKD were derived for UK patients included in the DISCOVER CKD cohort study using clinical records from the Clinical Practice Research Datalink linked to external databases. Patients with a history of transplant or undergoing dialysis were not included. HCRU and costs were stratified by CKD severity using the urinary albumin:creatinine ratio (UACR) and estimated glomerular filtration rate. Results: Hospitalisation rates more than tripled between low (A1) and high (A3) UACR categories and the mean annual per-patient costs ranged from £4966 (A1) to £9196 (A3) and from £4997 (G2) to £7595 (G5), demonstrating that a large healthcare burden can be attributed to a relatively small number of patients with later stage CKD, including those with kidney failure and/or albuminuria. Conclusions: HCRU and costs associated with CKD impose a substantial burden on the healthcare system, particularly in the more advanced stages of CKD. New interventions that can delay the progression of CKD to kidney failure may not only prolong the patient's life, but would also provide significant resource and cost savings to healthcare providers.

Indexed as

chronic kidney diseaseClinical Practice Research Datalinkcost analysishealthcare resource usehospitalisations

Identifiers

PMID36325010
PMCPMC9613420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.