Evidence map›Paper›PMID 36324820›Full record

ArticleFrontiers in pediatrics2022

Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study.

Brittney M Snyder, Tebeb Gebretsadik, Kedir N Turi, Christopher McKennan, Suzanne Havstad, Daniel J Jackson, Carole Ober, Susan Lynch, Kathryn McCauley, Christine M Seroogy and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Brittney M SnyderDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Tebeb GebretsadikDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Kedir N TuriDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Christopher McKennanDepartment of Statistics, University of Pittsburgh, Pittsburgh, PA, United States.
Suzanne HavstadDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, United States.
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin, Madison, WI, United States.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, United States.
Susan LynchDepartment of Medicine, University of California, San Francisco, CA, United States.
Kathryn McCauleyDepartment of Medicine, University of California, San Francisco, CA, United States.
Christine M SeroogyDepartment of Pediatrics, University of Wisconsin, Madison, WI, United States.
Edward M ZorattiDepartment of Internal Medicine, Henry Ford Health System, Detroit, MI, United States.
Gurjit K Khurana HersheyDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Sergejs BerdnikovsDepartment of Medicine, Northwestern University, Chicago, IL, United States.
Gary CunninghamDepartment of Genetics and Metabolism, Children's National Medical Center, Washington, DC, United States.
Marshall L SummarDepartment of Genetics and Metabolism, Children's National Medical Center, Washington, DC, United States.
James E GernDepartment of Pediatrics, University of Wisconsin, Madison, WI, United States.
Tina V HartertDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
ECHO-CREW investigators
Vanderbilt University Medical Center · USUniversity of Wisconsin–Madison · USChildren's National · USHenry Ford Health System · USUniversity of California, San Francisco · USCincinnati Children's Hospital Medical Center · USNorthwestern University · USUniversity of Chicago · USUniversity of Pittsburgh · US

Funding

Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Christian Rosas-Salazar · 2011 to 2026
$34.9M
The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI JOHNSON, CHRISTINE C, ZORATTI, EDWARD M · 2012 to 2024
$25.7M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Irene M Ong · 2013 to 2026
$22.5M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUG3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2016 to 2024
$19.3M
Hormones in allergic diseaseR01AI127783 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BERDNIKOVS, SERGEJS · 2017 to 2021
$2.0M
Identifying molecular pathways in childhood asthma pathogenesis by integrating newborn metabolic profiles and GWAS dataK01HL161257 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Brittney M Snyder · 2022 to 2026
$650k
NHLBI NIH HHS K01 HL161257NIAID NIH HHS P01 AI089473NIAID NIH HHS U19 AI095227NIAID NIH HHS U19 AI104317NIH HHS UG3 OD023282NIH HHS UH3 OD023282
6 · The paper itself

Abstract

Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70-0.99],

Indexed as

citrullineinfancylower respiratory tract infectionmetabolitesnewborn screening (NBS)

Identifiers

PMID36324820
PMCPMC9618869
OpenAlexW4306385498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.